In a finding that could help speed the understanding of diseases ranging from
cancer to osteoporosis, researchers in Utah are reporting development of a new
microscope technique that uses "silver nanoparticle" mirrors to reveal
hidden details inside bones, cancer cells, and other biological structures.
The method also can help identify structural damage in a wide variety of materials,
including carbon-fiber plastics used in airplanes, the researchers say. Their
study is scheduled for the March issue of ACS'
Nano Letters, a monthly journal.
In the new study, John Lupton and colleagues point out that one of the most
powerful, widely used tools for imaging hidden biological structures is fluorescence
microscopy, which requires the specimen to be treated with fluorescent dyes
or stains. But the dyes used to visualize the structures can kill living cells,
limiting the effectiveness of the technique, the researchers note.
The scientists improved on this technique by using an infrared laser to excite
clusters of silver nanoparticles, each about 1/5000th the width of a human hair,
placed below the material being studied. The particles focus intense beams of
light up through the sample to reveal information about the composition and
structure of the substance examined, the scientists say. In laboratory studies,
they used the new technique to view the iridescent green scales of the so-called
“photonic beetle,” whose scales may provide clues to designing new,
more powerful solar cells and computer chips, the scientists say.