Active Ingredients in Pharmaceuticals and Agrochemicals

Specific components of pharmaceuticals and agrochemicals can express medicinal, therapeutic or biochemical effects on living matter. These are referred to as Active Ingredients (AI).

Within the agrochemical industry, such substances as herbicides, pesticides or insecticides can be formulated with inert or excipient chemicals which can either active as a delivery vehicle or modulate an active ingredients adverse effects.

Being able to comprehend an active ingredient’s biological activity is a core part of determining whether or not it will be viable and effective in a particular application. The degree of the AI’s biological activity will often signify a directly proportional relationship between its dosage concentration and any beneficial effects, as well as showing a common correlation between increased adverse effects and higher doses.

How Are Active Ingredients Made?

The production and supply of agrochemicals is subject to very stringent and specific certifications and requirements and as such, every stage of the chemical formulation process must be strictly monitored and controlled.

Any active ingredients must be produced in one or more multiple-step, chemical batch processing facilities that are sufficiently equipped to manage complex organic syntheses.

When manufacturing the fine chemicals required for active ingredients there is no margin for error. This is a key reason that growing numbers of agricultural producers are outsourcing these precision batch processes to more specialized producers of fine chemicals around the globe.

The synthesis of active ingredients needs to be approached holistically, using reliable chemical manufacturing components in order to support processes that are made up of a number of sensitive steps. There are a range of chemistries that can be used for producing the AIs used in agricultural chemicals. These include:

  • Azo chemistry;
  • Alkylation;
  • Suzuki coupling;
  • Heterocyclic synthesis;
  • Grignard chemistry;
  • Phosphorus additive synthesis.

These synthetic processes allow modern day chemists to formulate active ingredients within clear and specific manufacturing parameters. These are then compounded with adjuvants to dosage-specific ratios in line with any relevant requirements or certifications that must be adheredto.

Active Ingredient Manufacturing with CABB

CABB Group GmbH is a global leader in the manufacture of fine chemicals, offering extensive experience in the production of starting materials, advanced intermediates and active ingredients for a wide array of agrochemical applications.

CABB's three custom manufacturing facilities, in Finland, Switzerland and the USA, can perform a range of different chemical synthesis processes as well as act as satellite facilities for client-specific manufacturing.

Using its hands-on expertise, CABB can offer made-to-order chemical intermediates and active ingredients on demand. Its high purity solvents are regularly used in chemical synthesis processes to form active ingredient precursors.

This information has been sourced, reviewed and adapted from materials provided by CABB Group GmbH and Nexam Chemical AB.

For more information on this source, please visit CABB


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