Measure the Coating Thickness on Individual Tablets and to Show the Tablet to Tablet Variation

Terahertz waves are unique in that they can measure the coating thickness on individual tablets and to demonstrate any variation in thickness to other similar tablets.

In-Line Probe

TeraView has recently produced an in-line probe which can placed into a tablet coating drum to monitor and control the coating thickness on individual tablets. The ILOL3000 takes around 100 readings per minute, which can therefore measure several thousand tablets over a complete coating run.

This date can then be graphed in real time to show any variation from tablet to tablet and may be used in conjunction with the wider control system to control tablet coating thickness, end point and alarm to alert of possible malfunctions.

In contrast to other techniques, the reading is absolute and so doesn’t require a complicated chemometric model. A huge range of coating types and thicknesses can be analyzed, with detection limits ranging from 30 microns to several mm.

TPI imaga 2000

Teraview is continuing to develop this unit so that it can measure additional properties such as density, moisture and Interface Index (a parameter used to quantify the level of adhesion between two layers). The off lineTPI imaga 2000 is a current example of this technology, and has already shown how important these factors are.

The new in-line system is envisaged as an improved version of TeraView's existing off line TPI imaga 2000 which generates 3D images of individual tablets. These images have often been shown to correlate the products performance for controlled or modified release products.

The TPI imaga 2000 has been a crucial piece of equipment for the design of these, and similar, products, assisting in identifying and quantifying critical quality attribute (CQA’s). The in-line ILOL3000 is the next vital piece in the measurement of these during process development, scale-up and ultimately manufacture.

This information has been sourced, reviewed and adapted from materials provided by TeraView Ltd.

For more information on this source, please visit TeraView Ltd.

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