Using Terahertz Spectroscopy to Analyse Crystalline Structure Analysis

Terahertz spectroscopy is extremely sensitive and has high specificity to both intermolecular and intramolecular vibrations in various chemical species. This enables its use in the investigation of the crystalline state of drug, and for terahertz pulsed imaging (TPI™) in particular to be used for determining protein 3D structure, folding and characterization: highly useful for proteomics and drug discovery. Additionally, TPI™ is very sensitive to DNA hybridization and other interactions.

Spectroscopy Products for Analyzing Drugs’ Crystalline Structure

TeraView has a range of spectroscopy products designed to provide rapid identification of the numerous crystalline forms (polymorphs) of drug molecules. These instruments can also display different solubilities, stabilities and bioavailability, which are key factors in the therapeutic efficacy of a drug.

With many different polymorphs of a drug, it is crucial that they are detected and identified so that the mechanism and dynamics of polymorphic interconversion is understood. Once this is known then an optimum form can be selected for further development and manufacture. As well as being able to detect the differences between pure specimens of the polymorphs, terahertz spectroscopy can also distinguish between specific polymorphic forms in the tablet formulation.

Terahertz Spectroscopy for Quantitative and Qualitative Analysis

The pharmaceutical industry uses various excipients in designing drugs, one of them being lactose. It is one of the most commonly used examples, and forms at least three different hydrates: the most widely used a-monohydrate, the α-anhydrate and a β-anhydrate form. Terahertz spectroscopy can differentiate between different hydrate forms using their terahertz spectra, which can be used for both quantitative and qualitative analysis.

Investigation of the terahertz region also enables qualitative and quantitative analysis of crystalline and amorphous materials due its unique sensitivity to lattice structure.  

This information has been sourced, reviewed and adapted from materials provided by TeraView Ltd.

For more information on this source, please visit TeraView Ltd.

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