Pharmaceuticals manufacturers worldwide are seeking more effective ways to perform the raw material analysis while complying with strict global regulations. The latest innovations in instrument miniaturization have helped manufacturers to perform lab-quality analysis at any point in their manufacturing process allowing stronger quality programs that comply with stringent regulations and achieving quality goals that ensure consumer safety and product efficacy.
The ability for manufacturers to bring the lab to the sample creates efficiency in material output enabling manufacturers to quickly receive materials and confidently put them straight through to production.
Handheld Raman Analyzers
Implementing handheld Raman analyzers helps make the verification of pharmaceutical raw materials more effective and efficient. Raman Spectroscopy is a powerful technique for compound identification because of its specificity and the ability to perform non-destructive analysis through sealed packaging. Raman analysis offers compound-specific spectra and enables the accurate identification and verification of a broad range of chemical compounds.
Figure 1 shows the spectra collected from a single sample at both 1064 nm and 785 nm excitation. The excitation at 1064 nm excitation enables the observance of very clear Raman bands and these bands enable definitive identification of the sample.
Figure 1. Displaying Raman shift
While using a Raman spectrometer with 785 nm or 532 nm laser excitation, many common pharmaceutical materials show considerable fluorescence. The signal is reduced by this and the acquisition time is increased reducing the number of peaks available for material verification and identification.
Many analyzers operating at 785 nm only verify a fraction of materials used in the manufacture of consumer goods and pharmaceutical products because of this chronic fluorescence interference. The Rigaku Raman FirstGuard™ with 1064nm can reduce and eliminate fluorescence issues for most sample types providing broader compound coverage.
FirstGuard™ is the first handheld Raman analyzer available in 1064, 785, or 532nm laser excitation to satisfy the needs of a range of pharmaceutical material verification and analysis needs. FirstGuard uses proprietary software that integrates an open architecture platform with user-defined settings, enabling control over the quality of methods that result in reliable and actionable Pass-Fail results. The 1064nm model's cooled InGaAs detector enables an improved signal to noise ratio over standard CCD detectors used in other closed 785nm systems, and the exclusive volume holographic phase transmission grating, with 95% spectral efficiency, delivers optimal sensitivity.
Figure 2. FirstGuard™ handheld Raman analyzer
This information has been sourced, reviewed and adapted from materials provided by Rigaku.
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