ProteomeLab XL-A/XL-I Analytical Ultracentrifuge from Beckman Coulter

The ProteomeLab XL-A/XL-I in-solution characterization of proteins, oligomers, aggregates, particles, colloids, and small structures delivers accurate results you can rely on time and again. In-solution characterization allows for testing in native conditions, meaning you determine the sample testing environment that best suits your needs.

The unique column-free separating technique of the ProteomeLab XL-A/XL-I measures the relative change in the distribution of molecular weights, providing an efficient way to measure heterogeneity, stoichiometry and self-associating systems. And, because the measurements are based on the first principles of thermodynamics and hydrodynamics, no standards or calibrations are required. As a result, you spend less time on setup and more time on discovery.

Multiple Detection Systems

The ProteomeLab XL-A is configured with a scanning UV/Vis detection system that provides sensitivity for low-concentration work and selectivity for optimizing detection based on the sample's maximum absorbance. The addition of Rayleigh Interference Optics provides the capability to measure the change in refractive index resulting from changes in sample concentration. This delivers increased accuracy and the ability to examine a greater concentration range with a wider selection of samples.

The ProteomeLab XL-I can collect data from both detection systems sequentially, to provide the broadest spectrum of data for protein characterization in solution.

Easy Sample Preparation

For easy sample preparation, inject as little as 15 µL to 120 µL of sample and reference solutions into opposing positions in the cell assembly, and place the assembly into the system. Up to 28 different sample/reference pairs can be studied in a single run, with each having a different set of solute/solvent conditions (pH, ionic strength, concentration). This provides data for accurate analysis in as little as three hours. Your sample can be retrieved for additional analysis.

Flow-Through Centerpiece Assembly

A pre-assembled cell features a flow-through centerpiece that saves you time. Sample and reference solutions can be directly injected in the cell and retrieved for additional analysis without assembling or disassembling the cell. A second hole above each channel allows the cell to be cleaned and rinsed (with tubing and syringe) and ready for the next run.

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