The Viscotek TDAmax is a comprehensive, research grade, temperature controlled, multi-detector GPC/SEC system suitable for the molecular weight and molecular size determination of proteins, natural and synthetic polymers, copolymers and other macromolecules.
The TDAmax comprises three components, the GPCmax integrated solvent and sample delivery module, the triple or tetra detector array (TDA), incorporating RI, light scattering, viscosity, optional UV detectors, and OmniSEC software. The combined columns and detectors are fully temperature controlled up to 80°C to ensure optimum detector stability, and the detectors being in series ensure maximum sensitivity.
The key features of the TDAmax are:
- Absolute molecular weight of small polymers, protein stability and protein aggregation with the help of right angle light scattering (RALS)
- Direct output of absolute molecular weight of polymers without extrapolation using low angle light scattering (LALS)
- Protein and polymer structure information using intrinsic viscosity detector for all sample and solvent types
- Molecular size in terms of hydrodynamic diameter and Rg
- Copolymer composition using single or multi-wavelength UV detector
- Autosampler incorporated for improving repeatability and increasing throughput
- Comprehensive functionality software featuring “two clicks from data to results’
- 3D absorption plot for chemical identification of each component
- 21 CFR part 11 compliant
- Complete suite of calibration and GPC/SEC calculation types.
Molecular weight and molecular weight distribution [also called polydispersity] are the most important parameters in polymer science. We use the Viscotek TDAmax as a tool to monitor the progress of reactions and to evaluate the extent of control in the polymerization reaction. When making new polymers this information is critical to our understanding and tells us if the material is forming properly and if the chemistry is working.
Jason Locklin, Assistant Professor, Department of Chemistry and Faculty of Engineering, University of Georgia