The Möbius® for Electrophoretic Mobility and Zeta Potential Measurements

The Möbius® zeta potential analyzer from Wyatt Technology offers dependable, reproducible, and non-destructive electrophoretic mobility and zeta potential measurements of macromolecules less than 2nm in radius, as well as micron-size nanoparticles, in most aqueous buffers.

The novel, highly sensitive electro-optical design integrates 31 parallel detectors, which help the Möbius® characterize even delicate biomolecules in a non-destructive manner at low applied voltage. The Möbius® interfaces with a basic autosampler for increased productivity and unattended overnight, multi-sample analyses.

An integrated dynamic light scattering (DLS) detector offers instantaneous size measurements so as to check potential sample degradation, and to establish zeta potential or surface charge.

The Atlas flow cell pressurization unit broadens the range of precise, repeatable mobility measurements to tricky samples such as proteins in high-salt buffers up to 1M NaCl. The flow cell volume is about 170µL, while the sample volume needed with the manually-loaded dip cell is as less as 65µL.

Key Features

The main features of the Möbius® are listed below:

  • Mobility: particles from 2nm to 50µm, in a pressurizable flow cell or manual dip cell
  • Sensitivity: 0.05mg/mL lysozyme (DLS), 1mg/mL lysozyme (mobility/zeta potential)
  • Temperature range: 4°C-70°C
  • Range of hydrodynamic radius Rh: 0.2-5000nm in the flow cell, and 0.2-200nm in the dip cell or quartz cuvette
  • DYNAMICS® software enables a complete set of analyses for nanoparticles and macromolecules including size, size distributions, net charge and zeta potential

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