MFP-3D-BIO Atomic Force Microscope System from Asylum Research

The MFP-3D-BIO offers excellent sensitivity and highly accurate images and measurements possible on an inverted optical platform. The NPS™ closed loop nanopositioning sensors on all three axes ensure distortion-free images on samples as small as proteins and as large as cells - in both air and liquid.

The cantilever deflection is measured by the MFP-3D to better than 20pm (8pm typical) without artifacts, making the MFP-3D ideal for force measurements such as unfolding single molecules or probing cell mechanics.

The standard is set by the MFP-3D-BIO for combining atomic force and optical microscopy in a single integrated tool specifically designed for biologists. The company’s team of optical engineers and biologists optimized the MFP-3D for use with the leading inverted optical microscopes to ensure that one gets the maximum benefit and productivity from the combination of these powerful techniques.

Key Features

The key features of the MFP-3D are:

  • High numerical aperture, water immersion, and TIRF objectives are all accommodated
  • No other AFM can match the MFP-3D's performance for optical integration, high resolution imaging, quantitative force measurements, and environmental controls.
  • All these optical microscopy techniques are supported including Brightfield, Phase Contrast, Epifluorescence, Confocal Laser Scanning, TIRF, FRET, FCS, FRAP, Ion Indicators (e.g. Ca2+ response)
  • The MFP-3D's exclusive X-Y scanned-sample design is essential and enables apertureless Near-field Microscopy (ANSOM), Raman and Tip-enhanced Raman Spectroscopy, Tip-enhanced Fluorescence, Fluorescence Lifetime Imaging (FLIM)

User Testimonials

I have been using the Asylum Research MFP-3D-BIO AFM for the last 5 years and I must say that the equipment is a treasure from all points of view. It is versatile, has powerful capabilities and high precision which along with excellent service it makes everyone’s life in the lab easier. The Innovation Group, the Australian representatives of Asylum Research, helped us twice in the past year in regards with our MFP-3D-BIO system. I was amazed how quickly they identified the issues and the damaged components of our machine. Then it was really remarkable how prompt the American team in Santa Barbara brought back to life our equipment. Thank you both, Innovation Group and Asylum Research!!! You have a very happy customer here at the University of Queensland.

Elena Taran, The University of Queensland

I am so pleased that I decided to purchase the MFP-3D-BIO AFM and am also quite happy with how great it has been to work with you folks at Asylum. There is huge excitement here and I do feel that it has allowed our work to be taken to a completely different level – and to enable us to make some pretty profound observations that may prove relevant for cancer diagnosis/prognosis and perhaps even therapy. The whole mechano field is just blowing wide open, not just in cancer but in an array of fields. We have created so much interest in using this approach in biology that there are loads of folks who want to collaborate, both inside and outside UCSF.

Valerie M. Weaver, Director and Professor, Center for Bioengineering and Tissue Regeneration , University of California at San Francisco

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