Zetasizer AT: On-Line Measurement of Particle Size using DLS

Malvern Panalytical's Zetasizer AT integrates the proven dynamic light scattering (DLS) technology of the Zetasizer Nano, bringing a new level of dimension to the process development and manufacturing field, allowing on-line measurement of nanoscale particle processes in real time.

The Zetasizer AT is built on 20 years of expertise in design and automation of process interfaces for analytical instruments. It is a fully automated nanoparticle characterization system that provides on-line lab quality results in a timely manner for process optimization.

Working Principle

Flow control valves and high precision pumps are used by an automated sample preparation system to extract the sample from a vessel or process pipe and dilute it to the preferred concentration. The extracted sample is degassed and pumped via the flow cell of the analyzer. Following analysis, the sample is released and the cycle is repeated. Results are displayed on the computer’s screen instantly and can also be connected to a LIMS or plant SCADA system.

The sampling, dilution, and degassing processes are controlled by the Malvern Panalytical Link II software using standard operating procedures (SOPs).

Key Features

The main features of the Zetasizer AT are as follows:

  • Sampling system reduces sample consumption
  • Convenient transfer of laboratory DLS methods to on-line system
  • Tracks changes in particle size with time and also determines when the end point is reached.
  • Real-time monitoring of processes involving nanoscale droplets or particles; e.g. homogenization
  • Degassing, sample extraction, and dilution are facilitated by automated sampling system, providing the required concentration and reducing operator input
  • Uses Malvern Panalytical's Universal Interface for system integrators (Malvern Panalytical Link II)
  • Enables easy batch measurements of samples from other areas in the process, thus also serving as a laboratory system

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