Axcend Portable High-Performance Liquid Chromatograph

Axcend Focus LC®, which is the latest advanced, completely portable, high-performance liquid chromatograph available from Axcend, can be hand-carried anywhere. Moreover, it can be used at any place, for example, within a laboratory, on a manufacturing line, or even in the field. This is the first time HPLC has been provided with this kind of flexibility.

The Axcend Focus LC® provides better sensitivity compared to other UV-absorption-based HPLC systems, generating accurate test results quickly, while using 1/500th the solvents and producing 1/500th waste.

Designed and built in the laboratories of Prof. Milton Lee at Brigham Young University as the world’s first completely mobile gradient liquid chromatograph, the Axcend Focus LC® offers new opportunities and better flexibility for carrying out mobile analyses.

  • Measures around 32 cm x 23 cm x 20 cm, with a weight of 7.82 kg (17.25 lbs)
  • Capillary columns with an internal diameter (ID) of 150 µm are filled with 1.7–3 µm fused silica particles (other materials and sizes are also possible)
  • Greater HPLC sensitivity via dual or single miniaturized LED UV-absorption-based detectors
  • Easy-to-use cartridge-based system enables quick tool-less installation and working
  • Requires considerably smaller solvent and sample volumes, and produces considerably less waste (as little as 1/500th)
  • Rechargeable battery or AC power for laboratory or field
  • Safe wired or wireless control and data output via connected tablets or computers using top Web browsers

HPLC Anywhere® becomes a reality with the new Axcend Focus LC®, a portable high-performance liquid chromatograph (HPLC). The Axcend Focus LC® is a shoebox-sized capillary solution that provides better sensitivity than other UV-Absorption-based HPLC systems. The system uses only 1/500th the solvents and generates only 1/500th the waste.

Its weight and size enable convenient usage at any place: from the lab bench to within a fume hood and from in-the-field analysis to the production line.

The Axcend Focus LC® uses dual or single on-column UV-Absorption Detectors suitably accommodated into a compact and user-friendly cartridge system. Axcend’s fused silica capillary columns have an internal diameter (ID) of 150 μm and are usually packed with 1.7–3.0 μm stationary phase particles (where other column dimensions and packing materials are possible).

The Axcend Focus LC®’s portable design also enables easy integration with auto-samplers and convenient pairing with mass spectrometers. It also ensures secure wired or wireless control and data output via connected devices.

Physical Specifications

Axcend Focus LC® (height x width x depth)

20.1 cm x 23.1 cm x 32.0 cm (7.9 in x 9.1 in x 12.6 in)
Weight (without cartridge): 7.82 kg (17.25 lbs)

Axcend Focus LC® cartridges (height x width x depth)

4.1 cm x 11.2 cm x 18.8 cm (1.6 in x 4.4 in x 7.4 in)
Single detector cartridge: 0.26 kg (9.0 oz.)
Dual detector cartridge: 0.29 kg (10.1 oz.)

Solvent and waste vials (height x diameter)

Solvent-A Vial: 6.0 cm x 1.6 cm (2.38 in x 0.63 in)
Solvent-A Vial (volume): 9.0 mL

Solvent-B Vial: 4.5 cm x 1.5 cm (1.75 in x 0.56 in)
Solvent-B Vial (volume): 5.0 mL

Waste Vial: 7.0 cm x 2.0 cm (2.75 in x 0.81 in)
Waste Vial (volume): 17.0 mL

Instrument Controls

Axcend Focus LC® cartridge

Basic one-way manual insertion/removal
Hand-tightened AssurLoc™ system offers leak prevention and ferrule alignment

Sample delivery

Topside port with automated or manual injection

Solvent and waste vial access

Front panel insertion into or removal from the Axcend Focus LC® front panel can be performed easily


One-button Start/Stop control

System Features


Up to 10,000 psi (689 bar)

UV-absorption detectors (single or dual)

255 or 275 nm wavelength

Capillary columns (single or dual)

Length: 50, 100, 150, 200, or 250 mm
Internal Diameter (ID): 150 μm

Packing material

Standard: 1.7–3.0 μm fused silica particles
Optional: Up to 5.0 μm, with other packing

Flow rate range

0.5–10 μL/minute

Delay volume

1.0 μL

pH range


The shoebox-sized Axcend Focus LC is a lightweight HPLC designed for both field and laboratory use.

The shoebox-sized Axcend Focus LC is a lightweight HPLC designed for both field and laboratory use.

Solvent and Sample Management

Number of solvents

Up to two: A and/or B

Injection volume range

External loop: 175 nL and greater
Internal loop: 4, 10, 20, 30, or 40 nL

Injection modes

Automated and manual

Gradient formation

High-pressure mixing, binary gradient

Flow ramping

User-defined using software interface

Primary wetted materials

  • PEEK
  • Fused Silica
  • Polyimide
  • 316 Stainless Steel

Solvent and waste storage

All vials can be easily accessed and integrated within the Axcend Focus LC®.


The Axcend Focus LC®’s secure wireless and wired HPLC output and control take place through computers that support HTML5. The main computer operating systems that are supported include:

  • Mac High Sierra and later
  • Windows v7 and higher
  • Ubuntu 16.04 and later

Power Specifications


100–240 V (AC); 50/60 Hz; 1.4 amp

DC (battery)

12 V (DC), 126 Wh (LiFePO4, with higher chemical and thermal stability compared to standard Li-ion batteries)

Operating time

10+ hours without recharging

Expected life

Over 2000 charge/discharge cycles

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