Posted in | News

Solvent Removal for Kilo Scale Preparative Chromatography

The Rocket 4D Synergy evaporator from Genevac is designed to provide a productive tool for automatic drying or concentration of very large volumes.

Configured with a 5-litre 316 stainless steel evaporation vessel – the Rocket Synergy 4D is proven to offer productive automated removal of solvent for labs running kilo scale preparative chromatography equipment.

Traditionally such labs have relied upon using several rotary evaporators to remove the large volumes of solvent from sample fractions. This time consuming manual process requires a dedicated operator to top-up dry ice in cold traps, feed the systems with more product and watch the systems continually. With a Rocket 4D Synergy evaporator you simply load your sample, select a method, press start, and walk away – the system will do the rest.

Compact in size the Rocket 4D Synergy allows you to dry or concentrate your samples with complete confidence as it uses proprietary vacuum technology to suppress solvent bumping and foaming – problems associated with sample loss when using large scale rotary evaporators.

Users wishing to dry volumes larger than five litres require the ‘Autofeed’ option, which enables the Rocket 4D Synergy to automatically draw in further chromatographic eluent ready for evaporation. The Rocket 4D Synergy controls product feed, drying and the discharge of condensed waste solvent without any external intervention. The autofeed system has an integrated rinse circuit which enables dried products to be automatically re-dissolved in a small volume of solvent at the end of the process. Alternatively, the same circuit can be used under manual control for solvent exchange, by selecting a different solvent for re-dissolve. Cleaning the Rocket 4D Synergy between cycles is very straightforward. The PTFE feed tubing is easily detached for cleaning or replacement and the vessel can be readily cleaned, wiped, inspected and even put in a dishwasher. The Rocket 4D Synergy also includes powerful cold traps that maximise solvent recovery protecting the environment and improving drying of samples.  

For further information please visit or contact Genevac on +44-1473-240000 / +1-845-255-5000 or email [email protected]  


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Genevac. (2018, June 08). Solvent Removal for Kilo Scale Preparative Chromatography. AZoM. Retrieved on January 27, 2022 from

  • MLA

    Genevac. "Solvent Removal for Kilo Scale Preparative Chromatography". AZoM. 27 January 2022. <>.

  • Chicago

    Genevac. "Solvent Removal for Kilo Scale Preparative Chromatography". AZoM. (accessed January 27, 2022).

  • Harvard

    Genevac. 2018. Solvent Removal for Kilo Scale Preparative Chromatography. AZoM, viewed 27 January 2022,

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback