Agilent Technologies 1290 Infinity LC

The Agilent 1290 Infinity LC is designed to provide highest speed, resolution and ultra-sensitivity. A new power range allows you to deploy any particle type, any column dimensions, or any mobile and stationary phases. Innovative technology components offer the next level of performance for UHPLC, RRLC and HPLC applications. With the revolutionary ISET technology the 1290 Infinity is the world’s first truly universal LC system as it can execute other HPLC and UHPLC methods and deliver the same chromatographic results without any change of the instrument or the original method. In short, it gives you infinite capabilities to solve all your analytical challenges in LC and LC/MS.

Typical performance – 1290 Infinity LC System

  • More speed, resolution and sensitivity
  • Superior mixing performance with Agilent Jet Weaver
  • Excellent retention time precision
  • Highest baseline robustness with Agilent 1290 Infinity DAD
  • Ultra UV sensitivity with Agilent 1290 Infinity DAD
  • Highest sensitivity for routine applications with Agilent 1290 Infinity VWD


  • Intelligent System Emulation Technology (ISET) provides seamless transfer of methods between LCs, regardless of the brand, delivering unchanged retention time and peak resolution
  • Infinite power range that combines ultra high pressure up to 1200 bar and high flow rates up to 5 mL/min for maximum chromatographic performance, compatibility, flexibility and investment protection
  • 1290 Infinity Binary Pump combines active damping with lowest delay volume down to <10 µL – facilitated by multi-layer technology in the new Agilent Jet Weaver mixer – for highest retention time precision and superior UV-detection sensitivity
  • Optical design in 1290 Infinity Diode Array Detector – including Agilent Max-Light cartridge flow cell – offers a new level of UV-sensitivity and baseline robustness, including fast spectral acquisition at data rates up to 160 Hz
  • Ultra sensitivity is achieved through revolutionary Agilent Max-Light cartridge cell with 60 mm optical path length
  • (typically noise: < ± 0.5 µAU/cm) providing more than 10 times higher sensitivity than the 1200 Series DAD and VWD
  • Next generation flow-through design of the 1290 Infinity Autosampler achieves lowest carry over (<0.004%) and highest precision for both large and small injection volumes without changing sample loops
  • 1290 Infinity Flexible Cube combined with the 1290 Infinity Autosampler to facilitate automatic backflushing of needle seat for a new benchmark in lowest carry over (typically <0.0010%, <10 ppm). Plus, support of generic valve applications with up to two QuickChange valves (feature will be supported in late 2010)
  • 1290 Infinity LC Injector HTC/HTS is designed specifically to meet the throughput and reliability demands of critical LC/MS applications, offering lowest carryover with dynamic load and wash (DLW) principle
  • Pull-out valve drive and user-exchangeable valve heads in the 1290 Infinity Thermostatted Column Compartment boosts usability and paves the way for ultra high-throughput, multi-method and automated method development solutions
  • ZORBAX Rapid Resolution High Definition (1.8 µm) LC columns facilitate easy, fast and secure method transfer from HPLC to UHPLC through identical column chemistries
  • Lab Advisor software – with intuitive diagnostic and monitor capabilities and alert functions to notify you of problems – helps you manage your lab for best chromatographic quality

Columns & Supplies

  • LC and LC/MS columns
  • LC and LC/MS Consumables


  • Compliance Services
  • Instrument Services
  • Software Services
  • Specialized Services
  • Lifecycle Services

1290 Infinity Module Overview

  • 1290 Infinity Binary Pump
  • 1290 Infinity Autosampler
  • 1290 Infinity Thermostatted Column Compartment
  • 1290 Infinity Diode Array Detector
  • 1290 Infinity LC Injector HTC/HTS
  • 1290 Infinity Flexible Cube

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