One Box Solution for Spectrometry—MiD® Platform

The proprietary MiD devices and accompanying software use miniaturized chip-based technology to deliver quick insights into biological or chemical samples and reactions.

Microsaic 4500 MiD®

Video Credit: Microsaic Systems plc

A single box houses the vacuum system, electronics, and computer in the 4500 MiD®. It can be positioned anywhere where a typical mass spectrometer system cannot be deployed and never requires a floor pump while providing the same performance.

The Microsaic MiDas small interface sample module makes it possible to deploy the 4500 MiD® with ease in a wide range of on-line, at-line, and off-line applications.

  • Small footprint permits placement anywhere in industrial or laboratory facilities
  • The system is fully integrated and reliable. No extra vacuum pumps or external computers
  • Easy to use, “plug and play” consumables
  • Low maintenance expenses and a front end that requires no tools

Chip-Based Technology

The 4500 MiD® is dependable, strong, and user-friendly, with an increased mass range, a completely tool-free front-end for enhanced control, an intuitive and strong user interface, and improved electronics.

It uses Microsaic’s three main patented chip-based technologies, the ionchip®, spraychip®, and vac-chip. Changes in front-end alignment have improved system uptime and decreased pollutants’ deposits downstream.

  • Vac-chip
  • Ionchip®
  • Spraychip®

Mass Range

The 1400 m/z mass range opens up a new set of applications, such as peptide analysis utilizing Nano LC-MS, which is appropriate for the 4500 MiD®’s highly effective ESI source and a tendency for repeated charging.

The Microsaic 4500 MiD® is simple to use and maintain and offers reduced solvent, nitrogen, and power usage to cut running expenses and give a more environmentally friendly mass detection solution.

Table 1. Technical Spec. Source: Microsaic Systems plc

Technical Spec  
Dimensions 55 x 35 x 25 cm (22 x 14 x 10 in.) (including PC, pump and exhaust)
Weight 32 kg (including PC, pump and exhaust)
Ion Source spraychip® – electrospray ionization source
Ionization Modes Positive and negative ESI
Sample Inlet Compatible with standard capillaries and unions e.g., 1/32” tubing
Flow Rate Range 0.3-2000 µL/min
Mass Analyzer ionchip® – quadrupole mass filter
Mass Range 50-1400 m/z
Mass Accuracy ± 0.3 m/z in full scan*
Mass Resolution 0.7 m/z ± 0.1 @ FWHM*
Sensitivity 10pg of reserpine yields a peak in SIM mode with a S/N ratio of 10:1 (RMS)
Interface vac-chip – off axis microengineered atmospheric pressure interface
Detector Electron multiplier
Dynamic Range 3-4 orders of magnitude
Scan Modes Full scan, SIM (8m/z channels), simultaneous scan/SIM, and timed SIM
Scan Rate m/z 1,500/s (7,500 pts/s)
Pumping System Integrated oil-free pumps (no floor pump needed)
Software Control Masscape® Clarity, PrepCon, Remote Operations Protocol
Connections Ethernet, 5 x USB
2 x digital in (e.g., LC trigger input), 2 x digital out
4 x in (e.g.; UV Trace), 4 x out (e.g., triggering external device)
1 x RS232 (e.g., syringe pump control)


Table 2. Utility requirements. Source: Microsaic Systems plc

Utility requirements  
Power Requirements Power: 250W (operating), 300 W (peak)
Line voltage: 100-240 V AC±10%
Line frequency: 50/60 Hz
Nitrogen Gas Pressure 2-6 bar (29-87 psi)
Purity (≥99,5%)
6 mm OD push fit connection
Pump Exhaust Exhaust connects to an 8 mm OD push fit

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