Bruker Introduces Ultima Investigator Microscope for In Vivo Imaging

Economical New Multiphoton Imaging System Provides Superior Sensitivity and Speed

Today Bruker announced the release of the Ultima Investigator Multiphoton Microscope for high-performance in vivo imaging.

Ultima Investigator utilizes a streamlined design that incorporates many of the innovative features found in Bruker’s industry-leading Ultima IntraVital and In Vitro models. Up to four close-coupled detectors maximize collection efficiency and, when combined with Bruker’s next-generation preamplifier, produce the signal-to-noise levels that enable high-speed imaging at depths up to 1 micron.

Ultima Investigator also utilizes a rotatable nose piece that allows for the off-axis imaging required for advanced, in vivo neural activity research.

In vivo imaging using multiphoton microscopy continues to be a growing area of interest in neuroscience research. Ultima Investigator optimizes our core multiphoton technology to produce superior sensitivity and flexibility for in vivo applications.

By focusing the Investigator’s design on imaging only, this high-end technology now becomes available to a large number of researchers. Early feedback indicates that the performance of the new hardware exceeds user expectations, and coupled with our well-known Prairie View software, is opening new avenues of research into in vivo cellular activity.

Stephen C. Minne, Ph.D. - General Manager of Bruker's Fluorescence Microscopy business

About Ultima Investigator

Based on Bruker’s point-scanning technology, Ultima Investigator incorporates an improved detection path to increase photon collection efficiency and next-generation preamplifiers for improved signal to noise. The microscope platform provides generous clearance for in vivo studies, and off-axis imaging capabilities for brain imaging applications.

Prairie View software provides links to other software platforms for data transfer and scripting, allowing closed-loop experiments during data acquisition. An optional resonant galvanometer enables high-speed applications, with full-frame rates of 30 frames per second and region-of-interest frame rates of over 500 frames per second.

Photoactivation and photostimulation options are also available. With its combination of streamlined features and add-on capabilities, Ultima Investigator delivers the ultimate value for in vivo studies in smaller labs and additional imaging bandwidth in larger labs.

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