Utilizing the BI-MwA to Determine the Molecular Weight of PLA

Polylactic acid, (polylactide, PLA) polymers are employed in an extensive range of commercial, biomedical, academic and pharmaceutical applications due to their biodegradability and biocompatibility. Applications include sutures, stents, and a wide range of uses in food packaging and disposable tableware.

However, the molecular weight of the polymer can affect the properties of the end product. Therefore quick and reliable characterization is vital to better understand manufacturing performance, processing, and structure-property relationships.

Utilizing the BI-MwA to Determine the Molecular Weight of PLA

Image Credit: Brookhaven Instrument Corporation

Molecular weight determination of PLA by solution-based techniques like Static Light Scattering (SLS) or GPC with refractive index detection is a challenge as a result of the low value for the refractive index increment, dn/dc. For example, the dn/dc of PLA in THF is 0.042 mL/g, this is 4.5 times less than a polystyrene solution with the same molecular weight and concentration in THF (dn/dc: 0.19 mL/g).

Utilizing the BI-MwA to Determine the Molecular Weight of PLA

Image Credit: Brookhaven Instrument Corporation

An industrial PLA sample was dissolved in THF and data was collected with a BI-MwA in batch mode. Commercial polymers contain substantial amounts of impurities and dust, which are a huge problem in light scattering. The BI-MwA’s closed flow system prevents entry of airborne dust after filtration. Also, the BI-MwA’s software features automated dust rejection algorithms. Both features reduce the effects of dust on measurement results.

Light scattering data is typically analyzed with the Zimm equation:

Utilizing the BI-MwA to Determine the Molecular Weight of PLA

Here, K is the Debye constant, a constant of the polymer/solvent system and proportional to the square of the refractive index increment, dn/dc1.

Polymer concentration, c, is determined when sample solutions are prepared, and ∆R is proportional to the excess scattered intensity and measured by the BI-MwA. The scattering vector, q is given by (4πn/λ)sin(θ/2). Here, n is the refractive index of the solvent, λ is the wavelength, and θ is the scattering angle

In order to determine molecular weight, the BI-MwA software generates a Zimm plot based on the Zimm equation. After extrapolation to zero angle and concentration, values for absolute molecular weight, Mw, radius of gyration, Rg and second virial coefficient, A2 are calculated and displayed.

For this sample:

Source: Brookhaven Instrument Corporation

. .
Mw 1.598 x 105 g/mol
Rg 32.3 nm (indicating either a stiff polymer chain or a broad molecular weight distribution)
A2 1.18 x 10-3 cm3 mL/g2 (indicating that THF is a thermodynamically good solvent for PLA)

 

This data shows that the BI-MwA can be used to determine the molecular weight of polylactides.

Utilizing the BI-MwA to Determine the Molecular Weight of PLA

Image Credit: Brookhaven Instrument Corporation

This information has been sourced, reviewed and adapted from materials provided by Brookhaven Instrument Corporation.

For more information on this source, please visit Brookhaven Instrument Corporation.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Brookhaven Instruments Corporation. (2021, January 07). Utilizing the BI-MwA to Determine the Molecular Weight of PLA. AZoM. Retrieved on June 17, 2024 from https://www.azom.com/article.aspx?ArticleID=19994.

  • MLA

    Brookhaven Instruments Corporation. "Utilizing the BI-MwA to Determine the Molecular Weight of PLA". AZoM. 17 June 2024. <https://www.azom.com/article.aspx?ArticleID=19994>.

  • Chicago

    Brookhaven Instruments Corporation. "Utilizing the BI-MwA to Determine the Molecular Weight of PLA". AZoM. https://www.azom.com/article.aspx?ArticleID=19994. (accessed June 17, 2024).

  • Harvard

    Brookhaven Instruments Corporation. 2021. Utilizing the BI-MwA to Determine the Molecular Weight of PLA. AZoM, viewed 17 June 2024, https://www.azom.com/article.aspx?ArticleID=19994.

Ask A Question

Do you have a question you'd like to ask regarding this article?

Leave your feedback
Your comment type
Submit

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.