Posted in | Materials Analysis

Freeslate and Wyatt Technology to Present Automated Biologics Formulation and Stability Studies Incorporating Dynamic Light Scattering

Wyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate.

Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on September 9, 2014 at 11:00 AM EST/ 4pm GMT. Register now at www.business-review-webinars.com.

Freeslate BFS and Wyatt DynaPro Plate Reader

Due to the inherent instability of proteins and their tendency to aggregate under certain thermal and chemical conditions, screening and stability studies are an essential part of the development process for biologic formulations. However, the time and resources associated with manual processes often restrict the number of formulations that can be screened. By automating formulation preparation, screening and stability studies companies can increase their productivity and throughput without the need for additional resources as well as broadening the formulation design space.

Russell Burge, Ph.D., Applications Scientist at Freeslate, will present Freeslate’s Biologics Formulation System (BFS), an integrated workspace system that performs fully automated formulation preparation, screening and stability studies for the development of biotherapeutics. The system supports a number of analytical tools, including Wyatt Technology’s DynaPro® Plate Reader II. Daniel Some, Ph.D., Principal Scientist at Wyatt, will introduce dynamic light scattering (DLS) as implemented in the DynaPro to quantify molecular size and aggregation state, assess aggregation propensity and determine formulation viscosity. When integrated with the Freeslate BFS, the temperature ramps and aggregation data provided by the DynaPro enable researchers to test more formulations, more rapidly, compared to manual operations, leading to greater productivity and confidence in the results.

Dr. Some, who also serves as Director of Marketing at Wyatt Technology, explained:

“Optimization of the biologic drug formulation process is a key consideration for biopharmaceutical companies who invest significant resources in preclinical drug development. The integration of the DynaPro Plate Reader II with the Freeslate BFS enables researchers to dramatically increase the throughput and design space of their analyses. By providing comprehensive, automated testing over a range of conditions in minimal time, the Freeslate BFS combined with the DynaPro successfully meets the needs of our customers who are looking for a solution to the challenges associated with the development of safe, stable and effective biologic formulations. This webinar will provide a great opportunity to discover the latest developments in the automation of biologics formulation screening and stability studies.”

The DynaPro® Plate Reader II is capable of running automated high throughput screening analyses to characterize protein formulations in standard 96, 384 or 1,536 microwell plates, under multiple conditions in a significantly reduced timeframe. The onset points of aggregation or melting may be obtained in the DynaPro via temperature ramps or chemical denaturing, making the DynaPro DLS plate reader the ultimate tool for developability and formulation screening for biotherapeutics.

To learn how laboratory automation can be applied to biologics formulation screening and stability studies, register now for the webinar hosted by Business Review at www.business-review-webinars.com. For more information regarding the DynaPro® Plate Reader II visit www.wyatt.com/Dynapro.

About Wyatt

With a long history of excellence in scientific instrumentation, Wyatt Technology is the recognized leader in innovative, quality light scattering instruments and software for determining the solution properties of macromolecules and nanoparticles in solution:

  • Molar mass
  • Size
  • Charge or zeta potential
  • Biomolecular interactions
  • Conformation and composition

Wyatt provides solutions for in-line multi-angle static light scattering (SEC-MALS), field-flow fractionation (FFF-MALS), composition gradients (CG-MALS), high-throughput and traditional dynamic light scattering (DLS), electrophoretic mobility (ELS), differential refractometry and differential viscosity. Through a staff comprising 20% Ph.D. scientists and many more dedicated and experienced support personnel, Wyatt's aim is to delight the customer with the best training, customer support and service available in the industry.

About Freeslate

Freeslate is a privately held company providing laboratory automation products that dramatically improve the productivity and innovation of drug development organizations. For more than a decade, Freeslate has been working with customers to automate complex chemical research processes. Our resulting product line includes solutions for protein and vaccine drug formulation development, small molecule solubility, and polymorph screening and process chemistry. We start with a scientific understanding of our customer’s bottlenecks and utilize our robust and proprietary automation platforms and integrated Lab Execution and Analysis (LEA) software suite to deliver solutions that make a difference. The company is headquartered in Sunnyvale, California, with direct sales and service in North America, Europe, and Asia. For more information, visit www.freeslate.com.

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