CP Kelco Reveals How Malvern GPC/SEC Technology Supports Its Manufacture of High Performance Biopolymers

Insight from CP Kelco, a global leader in the specialty hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation/size exclusion chromatography (GPC/SEC) in biopolymer manufacture.

Using GPC/SEC systems from Malvern Panalytical, the company has established analytical strategies that ensure consistent, high performance pectin and carrageenan grades from a wide range of different natural sources.

Pectin is found in a wide range of natural sources.

“Unfortunately not even all oranges are the same,” said Jan Larsen, Principal Scientist, CP Kelco “Since we extract biopolymers from a variety of citrus fruits and from seaweed, we face the task of dealing with multiple and variable feedstocks. An essential element of R&D is to efficiently identify optimal extraction conditions for each new feed so as to deliver a highly consistent product that can be used with confidence across the food, drink and pharmaceutical industries.”

“We exploit the full capabilities of the Viscotek tetra-detector GPC/SEC system to look at molecular weight (MW) distribution, structure or ‘branchiness’, intrinsic viscosity (IV), and to detect any unwanted chemical impurities.”

The pectin and carrageenan products made by CP Kelco are complex mixtures of copolymers, as in nature, and present a considerable challenge in terms of characterization and consistent product quality. The Viscotek tetra-detector array incorporates a refractive index concentration detector, a light scattering detector for absolute MW measurement, a viscometer for IV measurement and a UV detector for chemical identification. Each GPC/SEC analysis therefore provides extensive and detailed information about the product that is directly relevant to performance. These data are used to optimize the extraction conditions applied to any given feedstock.

“During processing, both locally and at other sites across the globe, we switch to an ‘abbreviated’ form of GPC/SEC called flow injection polymer analysis (FIPA),” said Jan Larsen. “This is not as informative as ‘standard’ GPC/SEC but measurements are much faster, making it very useful for extraction control. FIPA provides averaged values of MW and IV in around ten minutes, so we can quickly check that the extraction is proceeding as it should.”

FIPA can be implemented on a Viscotek system simply by changing to a different separation column. It provides averaged rather than distributed values for the sample because the column performs a much simpler separation of the bulk polymer from any impurities or low molecular weight material. This means that measurement is relatively quick. Using the FIPA and ‘standard’ GPC/SEC in tandem is, therefore, a beneficial strategy for optimizing the cost-efficiency of the technique within the manufacturing environment.

Malvern Panalytical, Malvern Panalytical, Viscotek are registered trademarks of Malvern Panalytical

About Malvern Panalytical

Malvern Panalytical provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern Panalytical’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Our products reflect Malvern Panalytical’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.

Malvern Panalytical systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.

Headquartered in Malvern Panalytical, UK, Malvern Panalytical has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com


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