Posted in | News

Reproducible Scale-up of Medicinal Chemistry Reactions

Asynt reports that medicinal chemistry specialists Charnwood Molecular (Loughborough UK) have been using the DrySyn MAXI heating system to successfully and reproducibly scale up syntheses within their contract research laboratories.

Dr Michael McKenzie, Head of Operations, said: “Here at Charnwood Molecular our experienced preclinical R&D team routinely investigate the development of small scale medicinal chemistry routes in order to facilitate the timely supply of up to 500g of a final compound to our clients for testing. Delivery of this initial key amount of compound for preclinical studies is accompanied by a new, robust and transferable scale-up route to go beyond that quantity in clinical phases. Investment in DrySyn technology has allowed us to reproducibly scale-up our customers’ synthetic reactions from the milligrams to hundreds of grams scale."

Used with a conventional laboratory hotplate stirrer, DrySyn MAXI heating blocks provide rapid, safe and controllable heating up to 250ºC, with excellent reaction visibility and powerful stirring. The DrySyn MAXI block accommodates any standard 3000ml round-bottom flask, and using an insert the block is easily adapted for 2000ml flasks. Heat-resistant handles on the heating block make for greater safety and convenience when moving these large flasks around the laboratory. Provision is made for a temperature probe should temperature feedback control or monitoring be required.

Using standard round-bottomed reaction flasks, the DrySyn MAXI heating system from Asynt provides safe and accurate temperature control for synthesis, distillation and reflux operations when larger volumes (up to 3 litres) are in use. For further scale-up, the DrySyn SuperMAXI heating block is available for both 4000ml and 5000ml sized flasks.

For further information on reproducible medicinal chemistry synthetic scale-up using the DrySyn MAXI heating block please visit https://www.asynt.com/product/drysyn-maxi/ or contact Asynt on +44-1638-781709 / [email protected].

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Asynt. (2018, February 02). Reproducible Scale-up of Medicinal Chemistry Reactions. AZoM. Retrieved on December 03, 2024 from https://www.azom.com/news.aspx?newsID=48738.

  • MLA

    Asynt. "Reproducible Scale-up of Medicinal Chemistry Reactions". AZoM. 03 December 2024. <https://www.azom.com/news.aspx?newsID=48738>.

  • Chicago

    Asynt. "Reproducible Scale-up of Medicinal Chemistry Reactions". AZoM. https://www.azom.com/news.aspx?newsID=48738. (accessed December 03, 2024).

  • Harvard

    Asynt. 2018. Reproducible Scale-up of Medicinal Chemistry Reactions. AZoM, viewed 03 December 2024, https://www.azom.com/news.aspx?newsID=48738.

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type
Submit

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.