Posted in | Thermal Analysis

Thermal Analysis of Pharmaceuticals

Thermal analysis of pharmaceuticals

A number of interesting application examples, presented in the "Thermal Analysis of Pharmaceuticals" webinar, demonstrate the use of thermal analysis techniques in the pharmaceutical industry. These have to do with the measurement and testing of physical properties. Typical examples include the investigation of polymorphic transitions, decomposition behavior, loss of weight on drying, and many other applications.

Thermal Analysis of Pharmaceuticals – Important Applications

Thermal analysis is mainly used to investigate polymorphism and the melting behavior of crystalline materials, or to measure the glass transition of amorphous fractions. The determination of the purity of active pharmaceutical ingredients is often used in quality control.

Thermal analysis also provides information on the compatibility of excipients, shelf life, and thermal degradation.

The moisture content and influence of relative humidity can also be studied. The testing of primary and secondary packaging materials, coatings, and blister packages is another important field.

Important Effects and Properties Measured by Thermal Analysis

The most important effects that can be analyzed by DSC are the melting point, melting range and melting behavior.

DSC is also used to determine the heat of fusion, purity, polymorphism, the glass transition, and oxidation stability.

The main applications of TGA are evaporation, desorption and vaporization behavior, thermal stability, decomposition kinetics, and the analysis of composition.

TOA or thermo-optical analysis is used to study the melting point, melting range and polymorphism using visual observation and video recording.

MP indicates the automatic detection of the melting point or melting range.

TMA is normally used to study the expansion or shrinkage of materials and the glass transition.

DMA is the most sensitive method for characterizing the glass transition of materials.

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