Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Sprays and aerosols can be developed more effectively by measuring spray particles and droplet size distributions in real time with Malvern Panalytical’s Spraytec laser diffraction technology. This technology provides reliable and reproducible droplet size data while meeting the particular needs of spray characterization.

UPDATE: Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Features and Benefits

Malvern Panalytical’s Spraytec, which incorporates more than 35 years of experience in spray applications, offers the data needed to completely comprehend spray and atomization processes. It will:

  • Measure across a wide size range (0.1 - 2000 microns) without requiring regular optics adjustments
  • Measure droplet size variations over time at up to 10,000 measurements per second
  • Produce precise, concentration-independent findings by applying a unique multiple-scattering analysis
  • Define broad spray plumes without running the risk of causing optical contamination
  • Simply expose the dynamic variations in spray particle size using its unique size history analysis software

How it Works

The Malvern Panalytical Spraytec employs laser diffraction to assess the size of spray droplets and spray particles. It accomplishes this by measuring the intensity of light dispersed as a laser beam passes through a spray. The data is then evaluated to determine the size of the droplets that caused the scattering pattern.

The primary components of the Spraytec system are as follows:

  • A transmitter module that houses the collimated laser light source used to illuminate the spray during measurement
  • A receiver module with one of two lenses (300 mm or 750 mm) to focus any light dispersed by the spray onto a series of detectors. These detectors reliably measure the intensity of light scattered by spray droplets from various angles.
  • An optical bench that keeps the transmitter and receiver aligned. The length of this bench can be adjusted to suit different uses, with the longest bench being 2.5 m long.
  • The Malvern Panalytical Spraytec employs laser diffraction to assess the size of spray droplets and particles. It accomplishes this by measuring the intensity of light dispersed as a laser beam passes through a spray. The data is then evaluated to determine the size of the droplets that caused the scattering pattern.

Specification

Source: Malvern Panalytical Ltd

General
Principle Laser Light Scattering
Analysis Mie and Fraunhofer scattering, including a patented multiple scattering analysis
Data acquisition rate Rapid mode: 10 kHz. Continuous mode: 1 Hz.
Maximum Measurement Time Rapid mode: 30 seconds. Continuous mode: 60 minutes
Measurement Triggering Internal: Based on transmission or light scattering levels. External: Based on TTL input or simple switch trigger.
External Device Synchronization Via 2 TTL trigger outputs.
Optics
Light source Max 4 mW He-Ne Laser, 632.8 nm.
Lens arrangement Fourier (parallel beam).
Lens Focal Length 300 mm and 750 mm.
Measurement range 150 mm at 0.5 µm, extending to greater than 1 m above 5 µm.
Detector
Arrangement 36-element log-spaced array.
Angular range 0.015 – 17 degrees.**
Alignment Automatic.
Sizing Performance
Particle size 300 mm lens: 0.1 – 900 µm (Dv50: 0.5 – 600 µm). 750 mm lens: 2 – 2000 µm (Dv50: 5 – 1600 µm).
Accuracy Better than 1%.***
Repeatability Better than 1%.***
Reproducibility Better than 1%.***
Software
21 CFR part 11 Enables an operating mode that assists with ER/ES compliance.
System Compliance
Laser safety Class 3R, IEC60825-1:2007 and CFR Chapter 1: Sub-chapter J: Part 1040 (CDRH).
Regulatory testing CE / FCC compliant. Meets requirements of the European Low Voltage directive.
Weight and dimensions
Laboratory systems 950 mm optical bench: 950 mm x 550 mm x 610 mm (36 kg). 1400 mm optical bench: 37 kg 1400 x 550 x 610 (37 kg).
Spray Facility Systems 950 mm optical bench: 950 mm x 550 mm x 650 mm (36 kg). 1400 mm optical bench: 1400 x 550 x 650 (37 kg).
System
Power 100/240 V, 50/60 Hz.
Product storage temperature -20 °C to +50 °C.
Operating temperature (°C) +15 °C to +40 °C.
Humidity 80% maximum for temperatures up to 31 °C, decreasing linearly to 50% at 40 °C. Non-condensing.
Ingress Protection (IP) rating IP65 when in normal use

*This defines the maximum allowable distance between the far edge of the spray plume and the Spraytec receiver lens.
**Lens dependent.
***Relates to the measurement of the Dv50 for NIST-traceable latex standards. Sample dependent.

Accessories

Aerosol Positioning Accessory

The Malvern Panalytical Spraytec aerosol positioning accessory allows users to accurately position aerosol cans or pump sprays in relation to the Spraytec laser diffraction measurement zone during spray droplet and particle size measurements.

This helps to reduce a substantial source of variability associated with spray measurements, allowing for consistent testing of domestic and personal aerosol products.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Air Purge Accessory

The Air Purge Accessory prevents spray droplets from accumulating on the Spraytec optics while measuring wide or concentrated spray plumes. This allows for routine characterization of products like paint sprays and agrochemical application systems.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Extraction Accessory

The Spraytec Extraction Accessory allows users to gather and capture spray droplets and particles while measuring spray particle size. This reduces spray particle recirculation during measurements while simultaneously managing risks associated with user exposure to spray droplets.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Inhaler and Nebulizer Accessory

The Spraytec Inhaler and Nebulizer Accessory enables users to accurately evaluate the droplet or dry powder particle size distributions produced by metered dose inhalers, dry powder inhalers, and nebulizers. Formulations can be quickly evaluated for appropriate dispersion qualities, providing researchers with the specific information needed to create innovative inhaled drug delivery solutions.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Nasal Spray Accessory

The Nasal Spray Accessory allows users to quantify the droplet or particle size distributions produced by nasal medication delivery devices in a reproducible manner, which is helpful for bioequivalence research and manufacturing quality control. Changes to the nasal spray device, formulation, or device actuation profile can all have an impact on the size of spray particles delivered.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Wet Dispersion Accessory

The Spraytec Wet Dispersion Accessory is a low-cost liquid sample dispersion device that can measure samples in both aqueous and non-aqueous dispersants.

Nasal Spray Device Measurement Using Laser Diffraction and the Spraytec

Image Credit: Malvern Panalytical Ltd

Support

Malvern Panalytical’s service plans protect the investment while always ensuring optimal performance.

Purchasing a Malvern Panalytical product is the beginning of a long-term collaboration that will continue for the instrument's lifespan. Malvern Panalytical will offer business assistance based on the user's needs.

Help Desk

  • Email and phone assistance.
  • Operators who answer the phone and make sure the query is addressed

Training

  • User training events

Software Downloads

  • A straightforward way of getting upgrades and new features

Malvern Panalytical’s Service Options- Choose the Right Plan

Malvern Panalytical Platinum Plan

For laboratories where maximum instrument uptime is vital to daily performance, the greatest degree of response, along with the ‘all-inclusive’ price plan, covers any unforeseen repair charges that might arise.

Malvern Panalytical Gold Plan

Maintaining the efficiency of the instruments will increase laboratory production. Malvern will maintain the instrument performance on schedule by providing specialized technical and software support in addition to that priority response.

Malvern Panalytical Bronze Visit

Preventative maintenance must be performed regularly in laboratories to maximize instrument performance.

Source: Malvern Panalytical Ltd

  Platinum Plan Gold Plan Bronze Visit
Annual PM/PV Test yes yes no
Telephone / Email Support yes yes no
Priority Response yes yes no
Emergency Breakdown visits* yes yes no
Parts Included yes no no
Technical & Software Support yes yes yes
IQ/OQ (Pharma)*** yes yes yes

*including labour & travel costs 
***available at an additional cost

Key Applications

The Spraytec system’s adaptability makes it ideal for use in various sectors, from batch release testing and product quality control to fundamental research and development.

It provides precise, reproducible spray size analysis in an easy-to-understand way, enhancing product understanding and control.

Orally inhaled and nasal drug products

Particle size largely determines the deposition pattern and bioavailability of therapeutic components supplied to the nasal mucosa and respiratory system via pump sprays and inhalers. The Spraytec system can track size changes caused by single-device actuation, allowing the dynamics of particle dispersion to be recognized and the device’s reproducibility to be enhanced. Rapid screening of formulations for appropriate spray characteristics reduces development time and enhances drug delivery effectiveness.

Routine Atomizer Characterization

The measurement of droplet size generated by atomizer systems is critical in enhancing process understanding and knowledge of spraying’s environmental impact, such as in coatings or agrochemical applications.

The Spraytec’s durable construction, effective air purge, and multiple scattering analysis allow measurements to be taken at high concentrations within a spray plume, giving the real-time data needed to detect particle size changes throughout atomizer operation.

Automotive Applications

The Spraytec’s capacity to measure at 10 kHz allows for the resolution of changes in droplet size noticed during rapid firing of automotive fuel injector systems. The availability of numerous triggering options guarantees that each injection event is completely recorded. The repeatability of atomization can then be evaluated and compared to combustion efficiency.

After using and analyzing my spray, I found Spraytec one of the best, most effective and easiest ways to characterize my spray. The Spraytec gives accurate and perfect results for the measurement of droplet size of spray. Moreover, it is very easy and safe to use, the laser is not so strong, so it doesn't effect you at all. Thank you Malvern Panalytical for such a great product.

Rizwan Minhas, LEGI Laboratory

This information has been sourced, reviewed and adapted from materials provided by Malvern Panalytical.

For more information on this source, please visit Malvern Panalytical.

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