Posted in | Protein Analysis | Dynamic Light Scattering

High-Throughput Strategies for Detecting Aggregates in Biotherapeutics

Add AZoM on Googleas a preferred source
From Nov 4 2025

Presented by: Karessa White, Ph.D. and Udayabagya (Bud) Halim, Ph.D. (Waters Corporation)
Presented Live: November 4, 2025

Aggregation and the generation of oligomers and high molecular weight species (HMWS) are still significant challenges in biotherapeutic development. Left uncontrolled, they can have an impact on product efficacy, safety, and regulatory approval.

To that end, authorities recommend the use of orthogonal approaches to detect and characterize particles of various sizes. In this GEN webinar, Waters’ expert speaker will discuss a systematic strategy for detecting oligomers, HMWs, and aggregates in biotherapeutics production.

Participants will learn about a high-throughput method that uses dynamic light scattering (DLS) and background membrane imaging (BMI) to analyze particles at various sizes, from nanometers to sub-visible and beyond.

Other Webinars from Waters | Wyatt Technology

Upcycling Polyolefins into Value-Added Thermoplastics

Upcycling Polyolefins into Value-Added Thermoplastics
Shining a Light on Conjugated Polymers with GPC-MALS

Shining a Light on Conjugated Polymers with GPC-MALS
Expanding the Characterization Toolkit with FFF-MALS

Expanding the Characterization Toolkit with FFF-MALS
Understanding Polymer Properties with Multi-Angle Light Scattering

Understanding Polymer Properties with Multi-Angle Light Scattering
Characterising of lentiviral & gammaretroviral vectors

Characterising of lentiviral & gammaretroviral vectors
Characterizing Polymers and Polymer Aggregates Using SEC-MALS

Characterizing Polymers and Polymer Aggregates Using SEC-MALS
Solving SEC/GPC Limitations with Multi-Angle Light Scattering and Asymmetric-Flow Field-Flow Fractionation

Solving SEC/GPC Limitations with Multi-Angle Light Scattering and Asymmetric-Flow Field-Flow Fractionation
Multi-Detector Asymmetric-Flow Field–Flow Fractionation for Nanoparticle Analysis in Complex Matrices

Multi-Detector Asymmetric-Flow Field–Flow Fractionation for Nanoparticle Analysis in Complex Matrices
Determination of critical product parameters for proteins from research to production

Determination of critical product parameters for proteins from research to production
Structural Characterization of Functional Polymers via Light Scattering and Differential Viscometry

Structural Characterization of Functional Polymers via Light Scattering and Differential Viscometry
Advancing Polymer Characterization with Light Scattering

Advancing Polymer Characterization with Light Scattering
Advanced Branched Polymer Characterization Using Multi-Angle Light Scattering

Advanced Branched Polymer Characterization Using Multi-Angle Light Scattering
Fundamentals of Dynamic Light Scattering for Biotherapeutic Development

Fundamentals of Dynamic Light Scattering for Biotherapeutic Development
Enhanced Compliance for SEC-MALS Using Empower Software

Enhanced Compliance for SEC-MALS Using Empower Software
High-Resolution Nucleic Acid and LNP Characterization Using Light Scattering

High-Resolution Nucleic Acid and LNP Characterization Using Light Scattering
Analytical Best Practices for GLP-1 RA Aggregation and Impurity Profiling

Analytical Best Practices for GLP-1 RA Aggregation and Impurity Profiling
High-Throughput Stability Screening Using Light Scattering Techniques

High-Throughput Stability Screening Using Light Scattering Techniques
Real-Time Bioprocess Optimization with Advanced PAT Solutions

Real-Time Bioprocess Optimization with Advanced PAT Solutions
Evaluating Low pH Elution Effects on AAV Transduction Performance

Evaluating Low pH Elution Effects on AAV Transduction Performance
Advanced CQA Characterization of GLP-1 Agonists with SEC-MALS

Advanced CQA Characterization of GLP-1 Agonists with SEC-MALS

Tell Us What You Think

Do you have a review, update or anything you would like to add to this content?

Leave your feedback
(Logout)
Your comment type
Submit

Materials Webinars by Subject Matter

Watch the
Webinar

More Articles from
Waters | Wyatt Technology

More Products from
Waters | Wyatt Technology

See all content from Waters | Wyatt Technology
Watch the
Webinar

Terms

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

Provide Feedback