The Calypso® II for Studying Biomolecular Interactions

The Calypso® II biomolecular interaction system from Wyatt Technology interfaces with a Wyatt multi-angle light-scattering detector - miniDAWN TREOS® or DAWN® HELEOS® II to enable analysis of biomolecular interactions without the need for labelling or immobilization to establish affinity, accurate molecular stoichiometry and kinetics of self-assembly, aggregation or disassociation of macromolecular complexes with the aid of composition-gradient multi-angle light scattering (CG-MALS).

The CALYPSO software designed for control, data acquisition and analysis is capable of analyzing self-association and hetero-association including simultaneous self- and hetero-association, high-order oligomerization, and multi-valent interactions.

Key Features

The main features of the Calypso® II are listed below:

  • Much faster and simpler than analytical ultracentrifugation
  • Advanced technology complements isothermal titration calorimetry (ITC), surface plasmon resonance (SPR), and other biophysical techniques for characterizing interactions
  • Basic unit can be fitted with a concentration detector such as a 3rd-party on-line UV absorption detector or Wyatt's Optilab® T-rEX

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