DynaPro Plate Reader III for Automated Characterization of Size, Stability and Molecular Weight

High-throughput dynamic light scattering (HT-DLS) and the automated DynaPro® Plate Reader III help in transforming nanoparticle and biotherapeutic development. The DynaPro outshines at high-throughput sizing and screening of biopharmaceutical and nanoparticle formulations to bring about novel workflows that cannot be attained with other DLS instruments.

The DynaPro® Plate Reader III offers a total solution in a standard well plate

  • Optimize protein buffers
  • Formulate nanoparticles
  • Develop stable biopharmaceuticals
  • Discover small-molecule and peptide drugs

Achieve the Complete Attribute Landscape

  • Solubility
  • Viscosity
  • Molar mass (Mw)
  • Size and size distributions (rh)
  • Aggregation and stability indicators (Tonset, Tagg, Tm, A2, kD)

Fast, Accurate, Easy

  • Measure from 4º to 85 ºC
  • Film- or oil-based evaporation seal
  • 21 CFR Part 11 compliant software
  • Sample volume as low as 4 μL
  • As sensitive as a cuvette-based DLS
  • User friendly experiment design in Dynamics
  • First and only A2 and Mw in a plate
  • Infrared wavelength not susceptible to fluorescence
  • Uses industry-standard 96, 384 or 1,536 microwell plates

Design High-throughput Experiments

High-throughput Experiments

Advantages

Comprehensive DLS experiments can be tackled and content-rich screening data can be explored like never before.

DLS experiments and screening data

Weeks of Experiments within Just Hours

Biologics: Colloidal and Thermal Stability

The DynaPro Plate Reader III performs high-throughput screening of biotherapeutic candidates, in order to define multiple properties of a plateful of candidates and formulations. The below presents the analysis of monoclonal antibodies (mAbs) for thermal stability.

Biologics: Colloidal and Thermal Stability

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