Particle Size Zeta Potential Analyzer—Nanotrac Wave II

The Nanotrac Wave II analyzer available from Microtrac MRB is an advancement over conventional DLS. The analyzer makes use of Reference Beating which involves amplifying the signal back to the photodetector. This leads to unmatched accuracy for the measurement of particle size, molecular weight, the concentration of colloidal systems, and Zeta potential.

The Nanotrac Wave II offers best-in-class particle analysis capability to users by leveraging novel probe technology, an optimized optical signal, and sophisticated algorithms. Regardless of whether the users’ material is ppm or near-finished product, the Wave II analyzer achieves sensitive, rapid, and accurate measurements of materials in the range of sub-nanometer to several microns.

Thanks to the Nanotrac Wave II’s novel design, it provides faster measurements with reliable technology, higher accuracy and precision, and particle size measuring to less than 0.8 nm. The comprehensive license-free software package computes the analysis data in compliance with ISO 22412 and approved based on CFR21 Part 11.

The Nanotrac range of instruments works based on the measurement principle of dynamic light scattering (DLS) in a 180° heterodyne-backscatter arrangement. In this configuration, a portion of the laser beam is combined with the scattered light. This is similar to the optical improvement of the scattered light. The range of particle sizes is between 0.8 and 6500 nm.


  • Fixed optics, specialized probe design, and 180° backscatter collection allow rapid and accurate measurement over the broadest concentration range—from ppm to near solids (40% w/v)
  • Peltier temperature control device
  • Increased optical signal ensures best-in-class accuracy compliments of Reference Beating
  • Several flow cell options—a titrator can be connected
  • Zeta potential can be measured closer to iso-electric point by avoiding errors due to electro-osmotic flow; ZP measurement varied from −200 to +200 mV

Product Advantages

  • Works in accordance with FDA 21 CFR Part 11
  • No “A priori” knowledge of particle size distribution needed – simply load your material and hit RUN
  • Material’s dynamic viscosity value can be manually chosen, which ensures consistency and accuracy (based on Stokes-Einstein)
  • Simple SOP configuration and administration, perfect for managing users over several shifts
  • Set zero is not needed—the blank measurement is integrated into the software
  • Display of cleanliness of sample cells and cuvettes, which includes error messages and alarms


Configured in laser scatter light (180°) for diluted and concentrated particle dispersions. Software is available for analyzing the Zeta potential (according to Smoluchowski), the electrophoretic mobility, and the particle size distribution by direct analysis of the Brownian motion.

Zeta Potential Range

Range of −200 mV to +200 mV, with a repeatability of +/− 1 mV in Zeta potential (with respect to PS Latex standard particles measuring 150 to 500 nm)



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