Rainin E4 XLS+ Electronic Multichannel Pipette from METTLER TOLEDO

Rainin multichannel pipettes offer industry-leading channel-to-channel consistency and set the standard for simplicity and performance in electronic pipetting.

Quantitative Analysis in Fewer Steps

The E4 XLS+ multichannel electronic pipette provides consistent high-throughput work. Quick loading, absolute precision, and ergonomic handling across all channels are hallmarks of Rainin.

Built to Perform

It is easy to configure and run protocols with the cushioned joystick selector. When dispensing multiple aliquots across many channels, users will get stable volume and identical speed throughout the process. Cycle counting can be automated so that users can concentrate on other details, and relieve their thumbs with options to auto-dispense or auto-mix. It is easy to save settings, which will allow users to duplicate an assay later.

Ergonomic Pipette

The E4 XLS+ is engineered for use with either hand and fits like a glove. It is very well balanced while pipetting. The carefully shaped fingerhook allows users to relax their grip. Exceptionally light operating forces and a silicone shock absorber integrated into the tip ejector make the E4 a top choice to work with. On LTS-fitted models, tip ejection force is merely 0.6 kg.

Compliant Pipette

To meet GLP/GMP compliance, the E4 facilitates password-protect protocols, pipette settings, and service alarms. Service records, status data, and cycles are fully tamper-proof.

Accurate and Precise

All piston movements are regulated by the onboard microprocessor, which maneuvers the piston at the set distance and at the set speed, irrespective of the user. The innovative stepper motor has 4,000 discrete steps, delivering highly precise liquid measurements. At the end of every pipetting cycle, the E4 XLS+ is capable of re-calibrating itself by resetting the zero point.


Faster Throughput

Rainin’s E4 XLS+ electronic multichannel pipettes help accelerate plate work. Dedicated modes simplify how users transfer multiple aliquots, carry out serial dilutions, and program complicated pipetting routines.


Absolutely Consistent Sample Pickup

Patented LTS tip and nozzle design enables remarkably easy mounting of multichannel tips. Perfect sealing is possible each time, without rocking or hand-tightening. Users will realize how easy it is to obtain absolutely consistent sample pickup throughout all channels.

Simplify Repetitive Pipetting

A multi-dispense feature eliminates the arduous labor of repetitive pipetting by computing the number of aliquots that can be dispensed from one pickup. Autopace streamlines repeat dispensing—users just need to click the joystick once and repeat dispense across a plate.


Manual is not required. The carousel navigation, large color screen, and joystick control of the E4 ensure highly intuitive and easy operation. From direct pipetting to challenging applications, this tool can perform it all. Its extended battery life provides a day’s worth of pipetting with less charging and will endure for thousands of recharges.


Highly Configurable

The E4s’ Admin Mode allows configuration of the pipette according to the user’s preference. For security or convenience, eliminate unnecessary modes or lock-in settings. Customized setting profiles can be created to “re-set” the pipette to the desired configuration.

PureSpeed on Board

Biomolecules from proteins to oligonucleotides to chromatin can be purified using E4 XLS+ adjustable spacer pipettes and Rainin’s PureSpeed™ tips. Users can unite fast and gentle processing of many samples with high elution concentration for a matchless combination. All E4 come pre-installed with the PureSpeed functionality.

GLP/GMP Secure

Compliance risks can be reduced. Onboard service data is very secure and can be quickly accessed. Calibration compliance errors can be avoided by password-protecting access to service interval alarms. Pipetting SOP deviations can be minimized by locking protocol settings.

Save the Protocols

Multiple custom protocols can be stored in the on-board memory. Users can concurrently review and select protocols by simply moving the joystick. Users will no longer have to re-enter preferred protocols repeatedly.

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