Rainin E4 XLS Electronic Adjustable Spacer Multichannel Pipette from METTLER TOLEDO

Put the E4 XLS adjustable spacer pipette’s 6 or 8 nozzles to work and efficiently transfer samples between different sized formats, for example, 24, 48, 96-well plates.

Smooth Width Adjustment

Rainin’s electronic E4 XLS Adjustable Spacer multichannel pipette is designed for transferring liquid samples between well plates, vial racks, tube racks, gel combs, trays, and other receptacles of varying sizes. It offers the ultimate ease and ergonomics in its range.

Built to Perform

The cushioned joystick control provides easy configuration and protocol working, and the spacing dial’s smooth manual movement renders uninterrupted width adjustment very simple. Users can now get consistent volume and identical speed for all process steps involved in a particular application.

Cycle counting can be automated so that users can focus on other details and relieve their thumb, with options to auto-dispense or auto-mix. It is easy to save settings so that an assay can be duplicated later.

Ergonomic design, speed, and legendary accuracy make Rainin’s electronic Adjustable Spacer the perfect variable-width pipette for proteomic, genomic, and cell culture applications.

Pipette volume range

The E4 XLS Adjustable Spacer multichannel pipette comes in three volume ranges:

  • 5–50 µl
  • 20–300 µl
  • 100–1200 µl

Compliant Pipette

To ensure GLP/GMP compliance, the E4 ensures password protection of protocols, pipette settings, and service alarms. Service cycles, service records, and status data are totally tamper-proof.

Perfect for Routine Micro-Well Work

The workflow can be transformed with the Rainin XLS Adjustable Spacer pipette. Users simply need to set the nozzle spacing, and then swiftly transfer samples between various plate and tubing formats.

The E4 XLS adjustable spacer pipette is well suited for typical micro-well work when users need to alter formats quickly.

Adjustable Spacer Multichannel Pipette | Rainin


Accurate and Precise

All piston movements are regulated by the onboard microprocessor, which maneuvers the piston at the set distance and the set speed, irrespective of the user. The innovative stepper motor has 4,000 discrete steps, delivering very precise liquid measurements. At the end of a pipetting cycle, the E4 XLS adjustable spacer is engineered to re-calibrate itself by resetting the zero point.


Fast Format Change

Continuously variable spacing enables nozzle spacing between 9–14 mm on 8-channel models and 9–19 mm on 6-channel models, ideal for pickup from 96-well plates and dispensing to 24-well plates or tubes, or vice versa. Effortless one-hand adjustment allows on-the-fly altering after aspiration and before dispensing. Spacing marks provide a quick visual aid, or the adjustable detent can be set for repeatable spacing without viewing.


Absolutely Consistent Sample Pickup

The patented LTS tip and nozzle design renders mounting of multichannel tips remarkably easy. Perfect sealing is possible each time, without rocking or hand-tightening. Users can realize how easy it is to obtain an absolutely consistent sample pickup throughout all channels.

Simplify Repetitive Pipetting

Multi-dispense helps eliminate the arduous labor of repetitive pipetting by computing how many aliquots can be dispensed from one pickup. Autopace streamlines repeat dispensing—the joystick has to be clicked once for dispensing to be repeated across a plate.


Manual is not required. The carousel navigation, large color screen, and joystick control of the E4 make the operation highly intuitive and easy. From direct pipetting to challenging applications, this tool can perform it all. Its extended battery life provides a day’s worth of pipetting with less charging and will endure for thousands of recharges.


GLP/GMP Secure

Compliance risks can be reduced. Onboard service data is very secure and can be quickly accessed. Calibration compliance errors can be avoided by password-protecting access to service interval alarms. Pipetting SOP deviations can be minimized by locking protocol settings.

Highly Configurable

The E4s’ Admin Mode allows configuration of the pipette according to the user’s preference. For security or convenience, unnecessary modes or lock-in settings can be eliminated. Customized setting profiles can be created to “re-set” the pipette to the desired configuration.

Save the Protocols

Multiple custom protocols can be stored in the on-board memory. Users can concurrently review and select protocols by simply moving the joystick. Users will no longer have to re-enter preferred protocols repeatedly.

PureSpeed on Board

Biomolecules from proteins to oligonucleotides to chromatin can be purified using E4 XLS adjustable spacer pipettes and Rainin’s PureSpeed™ tips. Users can unite fast and gentle processing of many samples with high elution concentration for a matchless combination. All E4 come pre-installed with the PureSpeed functionality.

Faster Throughput


Rainin’s E4 XLS electronic adjustable spacer pipettes help to accelerate plate work. Dedicated modes simplify how users transfer multiple aliquots, carry out serial dilutions, and program complicated pipetting routines.

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