The ability to preserve samples for extended periods of time is crucial especially in the histology field.
BINDER’s ultralow temperature freezers (Figure 1) help Propath to preserve histological tissue samples under extreme conditions. Propath is a British laboratory service provider for molecular pathology and histopathology, focusing on preclinical safety evaluation of medical products, pharmaceuticals, and chemicals. Moreover, the GLP-certified laboratory service provider validates new therapeutic antibodies and aids toxicology studies. It has more than three decades of experience in the field of research and regulatory studies.
Figure 1. BINDER’s ultralow temperature freezer
Histopathology and Molecular Pathology
Molecular pathology and histopathology make significant contribution in the work dealing with diseases and cancers. Histopathology is preferred over other options for cancer diagnosis. Surgical specimens or biopsies are the typical form of tissue samples. In this process, tissue sections are stained using special methods for subsequent microscopic analysis. Highly accurate diagnosis can be performed with the help of these histological sections. Besides determining and categorizing cancer cells, histological diagnoses enable detection of tumors in the early stage. Histological diagnoses can now be performed using tiny sections of tissue, thanks to today’s sophisticated techniques.
Molecular pathology is the latest special discipline in the field of pathology, involving the use of morphological analysis and molecular biology methods together in tissues and cells. This combination allows for acquiring specific information about the causes, types, prognosis, and curing of a variety of diseases.
Role of BINDER’s Solution at Propath
Preclinical safety evaluation of new pharmaceuticals and agents and getting well-defined, reproducible results and high-quality statements are the area of focus of the research at Propath. The ability to preserve samples for extended periods is essential for all pathological processes. The samples are maintained at temperatures down to -86°C for several weeks to several years. Therefore it is essential to have a 100% reliable cooling system to perform an in-depth overall analysis.
Figure 2. BINDER’s UF V ultralow temperature freezer
To meet this requirement, Propath uses BINDER’s UF V ultralow temperature freezer (Figure 2) for human tissue sample analysis for toxicology studies. Stewart Jones, Director of Molecular Pathology at Propath (Figure 3), said that a user-friendly freezer that has the ability to store and properly place the tissue samples is crucial to achieve high-quality products. Furthermore, the system must be completely reliable and capable of delivering an emergency service with a security backup. These are all the reasons behind the selection of BINDER’s UF V ultralow temperature freezer, Jones added.
Figure 3. Stewart Jones, Director of Molecular Pathology analyzing human tissue samples
Jones further said that the decisive factor in the selection of BINDER’s equipment was its feature of personalized access control through RFID technology (Figure 4). This technology provides protection to highly sensitive samples from unauthorized access by third parties, allowing only staffs who have been certified by the lab head to access the freezer utilizing their code card. Furthermore, the freezer features a data readout function, which allows monitoring temperatures over extended periods and providing extensive coverage relating to data analysis.
Figure 4. Personalized access control via RFID
Key Features and Advantages of BINDER System
The following are the key features of BINDER UF V 500 series ultralow temperature freezer:
- Reliable long-term storage at -86°C
- Multi-stage security concept with data storage and emergency service
- Electromechanical door lock that can be opened by a click of a button
- Personalized access control through RFID that avoids unauthorized access
- Documentation via user protocol
- Temperature data logger with USB port
- Around-the-clock exchange service upon agreeing to a maintenance contract
The following are the application fields of BINDER UF V 500 series ultralow temperature freezer:
- Pharmaceutical industry
- Clinics and university hospitals
This information has been sourced, reviewed and adapted from materials provided by BINDER GmbH.
For more information on this source, please visit BINDER GmbH.