BASF Develops Novel Packaging System for its Pharmaceutical Excipient Kollidon

BASF has designed a packaging system called PeroXeal that offers better protection for Kollidon, a pharmaceutical excipient based on polyvinylpyrrolidone (PVP), against exposure to oxygen and chances of being oxidized,which in turn decreases the peroxide level of Kollidon.

PeroXeal will protect the pharmaceutical excipient Kollidon® even better against penetration by oxygen and subsequent oxidation. Photo: BASF

This makes the excipient compatible for application in oxygen-sensitive formulations. PVP, under the trade name Kollidon, is utilized as a disintegrant and binder in tablets.

BASF’s Head of Global Business Management PVP, Dr. Boris Jenniches stated that the PeroXeal packaging system sets new quality standards for excipients by offering purity and formula stability and thus helps pharmaceutical manufacturers to obtain better levels of patient safety. The new packaging concept considerably decreases the peroxide levels of Kollidon to a value equivalent to that of naturally-based raw materials, making Kollidon a suitable replacement to natural counterparts, he added.

In general, as a synthetic polymer, Kollidon demonstrates minimum variability in processing when compared to naturally-based raw materials. The PeroXeal packaging system extends Kollidon’s shelf life and reduces the amount of byproducts in the formulation. The packaging system’s heat-sealed and multi-layered plastic film is utilized as an inner packaging material. The packaging material is eco-friendly, as it does not comprise aluminum. The PeroXeal transparent film retains the stability of the Kollidon, as it can stay sealed until the usage of the product.

The PeroXeal packaging concept is already being used with major Kollidon products manufactured at the Minden and Ludwigshafen facilities. BASF will supply all Kollidon grades with its new packaging technology beginning from 2013.

Source: http://www.basf.com

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