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MALS detector for Size Exclusion Chromatography and Field Flow Fractionation

Postnova Analytics PN3621 MALS detector sets a new standard for sensitive, precise and flexible Multi-Angle Light Scattering detection for Size Exclusion Chromatography (SEC) and Field Flow Fractionation (FFF) systems.

The detector simultaneously measures the intensity of scattering at 21 angles which enables the precise calculation of the absolute molecular weight of proteins, natural and synthetic polymers, and also molecular size expressed as the radius of gyration, Rg.

Incorporating the broadest range of working angles (7° - 164°) in a commercially available light scattering detector the Postnova PN3621 MALS ensures unmatched precision in molecular weight and particle size determination. Employing 21 angles of light scattering detection allows the PN3621 to achieve better results, especially with complex or high molar mass polymers, particles and protein aggregates.

The precision of molar mass and particle size determination is not only dependent on the total number of angles available, but also on the number of low detection angles which can be used for calculation. Angles below 35° are crucial for precise molar mass and size determination of branched polymers, high molar mass macromolecules, protein aggregates and particles. The Postnova PN3621 MALS offers a complete set of stable and sensitive low angle detectors at 7°, 12°, 20° and 28°. This high sensitivity means detecting even small peptides at low concentrations is not a problem.

The Postnova PN3621 MALS safeguards your large and potentially fragile protein aggregates, high molar mass macromolecules and particles by incorporating a vertical ‘clean by design’ flow cell where the sample can easily pass through without any alteration. For maximum flexibility the Postnova PN3621 MALS allows you to read-in up to 3 external analogue signals. A single software platform is available for the PN3621 MALS and the full suite of Postnova SEC/FFF detectors (RI, UV, Viscometer, DLS, ICP-MS). The PN3621 is very compact and lightweight saving valuable laboratory space and enabling you to easily transport and use the detector in different locations.

Because of its unique design and advanced performance features, the PN3621 MALS is ideally suited for the most challenging applications. For further information please visit or contact Postnova Analytics on +44-1885-475007 / [email protected].

Founded in 1997, Postnova Analytics is the inventor and leading international supplier of Field-Flow Fractionation (FFF) systems for markets including biopharmaceuticals, polymers, materials, nanotechnology and environmental sciences. Leveraging its unique and patented modular FFF - Light Scattering Platform, Postnova has been able to provide high performance solutions to a wide range of applications. Today the company's growing product portfolio includes Flow FFF, Centrifugal FFF, Thermal FFF, Size Exclusion Chromatography (SEC), MALS and DLS Light Scattering.  Postnova ( is located and headquartered in Landsberg am Lech (Germany) and has subsidiaries in the USA, UK and Finland. These offices, in conjunction with a highly qualified and trained distribution network, provide informed local support to customers worldwide.


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