A NEW PAT FOR WET GRANULATION

Over the past decade the symbiotic nature of Quality by Design (QbD) and Process Analytical Technology (PAT) has become clear. In the simplest of terms QbD systematically identifies what must be measured, and controlled, while PAT provides the necessary measurements, in the required timeframe. Wet granulation, and more specifically high shear wet granulation (HSWG), is a valuable process for the pharmaceutical industry, particularly for the preparation of tableting blends, but it remains challenging from this perspective. There is still debate over what can be most usefully measured and consequently the most appropriate PAT.

Our latest whitepaper, featured in Pharmaceutical Technology, demonstrates the value of dynamic powder flow measurements for the development and optimisation of wet granulation processes, drawing on data from two experimental studies. It shows how:

  • the FT4 Powder Rheometer® can be used to measure granule properties that correlate directly with the Critical Quality Attributes (CQAs) of tablets.
  • the Lenterra Flow Sensor system, a new PAT for real-time measurement, enables complementary, continuous in-line monitoring.

Used together these technologies present an integrated solution for HSWG monitoring and control.

To access your copy please visit the Pharmaceutical Technology website.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Freeman Technology. (2018, September 27). A NEW PAT FOR WET GRANULATION. AZoM. Retrieved on August 18, 2019 from https://www.azom.com/news.aspx?newsID=49725.

  • MLA

    Freeman Technology. "A NEW PAT FOR WET GRANULATION". AZoM. 18 August 2019. <https://www.azom.com/news.aspx?newsID=49725>.

  • Chicago

    Freeman Technology. "A NEW PAT FOR WET GRANULATION". AZoM. https://www.azom.com/news.aspx?newsID=49725. (accessed August 18, 2019).

  • Harvard

    Freeman Technology. 2018. A NEW PAT FOR WET GRANULATION. AZoM, viewed 18 August 2019, https://www.azom.com/news.aspx?newsID=49725.

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Submit