AVANCE NEO: Take NMR Research to Even Higher Performance Levels

The AVANCE NEO from Bruker represents the next generation in the highly successful AVANCE series product line. It was established to be the global technology and market leader in NMR.

Although its predecessor, the AVANCE III HD architecture, has provided cutting-edge NMR performance already, the AVANCE NEO pushes the performance levels even further. It features even quicker control, better dynamic range and greater scalability and flexibility.

The AVANCE NEO is based on a ‘transceive’ principle, which means that each NMR channel has both transmit and receive abilities. So each channel is its own separate spectrometer with the complete RF generation, transmission and receive infrastructure. This architecture offers the maximum flexibility with regards to multi-channel operation and instrument configuration. Multi-receive experiments are easily executed with this new technique.

Furthermore, the AVANCE NEO has the concept of an embedded acquisition server and an associated client-server software architecture (TopSpin 4 and higher). This ensures the spectrometer is independent of the client computer, thus providing the user the chance to control the system via operating system and location of choice (as in principle users can control the system via the cloud).

The AVANCE NEO, with its frequency range extended to over 1.5 GHz, and with a variety of functional enhancements in setup, memory buffers, diagnostics, etc, is well-positioned to aid as the research platform of choice for the existing and next generation of NMR spectroscopists.

Technical Details

Taking Rf Generation and detection one step further

With the AVANCE NEO, the most innovative RF generation and a new generation digital receiver are united in a unique transceiver technology. Each channel is provided with four independent numerically controlled oscillators (NCOs) and a single receiver. Frequency, phase, and amplitude can be concurrently set in 12.5 nanoseconds. Each transceiver features 4 Gb of Waveform memory allowing the most intricate sequences and shapes to be performed.

The receiver works with a 1.852 GHz intermediate frequency, allowing spectrometer frequencies beyond 1.25 GHz. The analog digital converter offers the acquisition of digitally filtered spectra with up 7.5 MHz sweep width. FIDs are collected into double precision data preventing any chance of data overflow.

Introducing wide-band Rf amplifiers

The AVANCE NEO is fitted with novel wide-band amplifiers, thus removing the need for individual low-band and high-band amplifiers. These amplifiers are standard for liquids applications and will offer total coverage of all frequencies with more than 100 W in the high frequency range and more than 500 W in the range of heteronuclei. Higher power amplifier is used in instruments fitted for imaging or solid-state NMR applications.

HPLNA for optimal sensitivity and minimum perturbations

The HPLNA offers highest performance for both liquid-state and solid-state spectroscopy. While the new GaAs technology allows the maximum sensitivity, the novel 4kW peak power active Transmit/Receive switch offers total linearity in the transmit path of the spectrometer, delivering vital selective excitation performance for any NMR application. Along with the new AVANCE NEO electronics, it is currently possible to exhibit a complex tuning and matching curve.

As a result of its well-designed filtering and packaging, the HPLNA is practically immune to electromagnetic interferences, thus avoiding any pick-up from undesirable external RF sources, such as HDTV. This brings about optimal sensitivity while simultaneously reducing the risk of disturbances due to digital communication around the NMR laboratory.


The Digilock uses maximum speed FPGAs, the state-of-the-art analog-to-digital and digital-to-analog converters with clock rates up to 320 MHz, and offers on-the-fly high speed digital signal processing, thereby enabling locking on complex deuterated solvents with numerous solvent peaks. Along with the newest high speed converters and rapid digital signal processing, this concept offers crucial performance with better immunity against external RF interferences and higher precision. Coupled with cold deuterium pre-amplifiers integral in the design of all Bruker’s CryoProbes, unparalleled stability and lock sensitivity can be realized.

SmartVT and the SmartCooler

The SmartVT is a unique, new Variable Temperature (VT) architecture, and comprises of a modular, plug-and-play multi-channel temperature control system coupled with the new SmartCooler. It adds to the overall spectrometer stability and NMR probe performance. The SmartVT controller has been greatly improved by adding novel airflow monitoring and regulation features, as well as the potential to manage up to four heater channels, while monitoring up to nine thermal sensors, and at a much higher precision and regulation speed than before.

The latest SmartCooler, Bruker’s new VT gas pre-conditioning unit for Bruker’s NMR probes, integrated with the new SmartVT, allows the NMR sample’s temperature to be extremely accurately monitored and controlled, thus ensuring the NMR results are unaffected by laboratory instabilities., e.g. in the VT gas supply of the laboratory and daily cycles in temperature.

The direct communication between variable temperature controller and lock allows features such as the NMR Thermometer, and safety features such as temperature limitations according to the selected solvent.

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