"The ability to make multimaterial microscale optical elements using 3D printing could aid in the miniaturization of optical devices used for medical treatments and diagnoses," said Maruo. "This could improve the ability to use these devices in or on the body while also enabling them to be disposable, which would help provide an advanced and safe medical diagnosis."
Optimizing color stereolithography
Stereolithography builds up a high-precision 3D structure by using a laser to harden light-activated materials known as photocurable resins in a layer by layer fashion. Microfluidics are often used to hold the liquid resins, but it is challenging to keep the different resins from contaminating each other when switching materials without creating large amounts of waste or forming air bubbles in the printed object.
In the new work, the researchers developed a way to hold the various materials in a droplet state, which allows them to be more easily exchanged in a closed space such as a microchannel without creating waste. To suppress air bubbles, the 3D-printed structure is moved around inside the resin each time a resin is replaced. They also integrated a two-step process for cleaning the 3D printed structure when the resins are changed to completely prevent cross-contamination.
To implement this optimized approach, the researchers created a palette to hold multiple resins and placed it, two cleaning tanks and an air blow nozzle on a motorized stage. "All the processes, including 3D printing, resin replacement, bubble removal and cleaning are sequentially carried out using software we developed," said Maruo. "This allows multicolor 3D microstructures to be created automatically."
Creating multicolor 3D structures
The researchers tested the approach by placing various types of photocurable resins in a palette and using them to create 3D microstructures. For one of these demonstration structures, a tiny multicolor cube just 1.5 millimeters across, the 3D printing system exchanged five colors of resin 250 times during a 6-hour fabrication process. The researchers also showed that adjusting the number of layers of multicolor resins made it possible to adjust absorbance of each part of the structure, allowing them to create microstructures with colors such as black by combining layers of red, blue, green and yellow.
"This method can be applied not only to multicolor resins but also to a wider variety of materials," said Maruo. "For example, mixing various ceramic micro- or nanoparticles with a photocurable resin can be used to 3D print various types of glass. It could also be used with biocompatible ceramic materials to create scaffolds for regenerating bones and teeth."
The researchers are now working to shorten the time required for processes such as resin replacement and bubble removal to allow for even faster fabrication. They also plan to use technology they previously demonstrated to build a multiscale fabrication system in which the fabrication resolution can be changed from less than a micrometer to several tens of micrometers by modifying the focusing lens and laser exposure conditions.
Paper: T. Maruyama, H. Hirata, T. Furukawa, S. Maruo, "Multi-material microstereolithography using a palette with multicolor photocurable resins," Opt. Mater. Express 10, 10, 2522-2532 (2020). DOI: https://doi.org/10.1364/OME.401810.