With intelligent angle selection to avoid errors, Litesizer DLS provides best-in-class particle sizing, while MAPS technology delivers the highest peak resolution. By identifying sedimentation and agglomeration during measurement, continuous transmittance monitoring improves measurement accuracy.
Addressing aging effects and reducing the electrical gradient, cmPALS and Omega Cuvette, which are exclusive to the system, increase zeta potential accuracy and repeatability.
Additionally, Litesizer DLS provides fluorescence and polarization filters for particle concentration measurements in both single-angle and three-angle MAPS modes, as well as for particle size measurements.
How to use the Litesizer DLS Dynamic Light Scattering Instrument | Quick Start Guide | Anton Paar
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Litesizer DLS 701
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- An advanced dynamic light scattering device with all modes
- Determination of concentration for up to three size classes
- Particle sizing from 0.3 nm to 15 µm
- Fluorescence and polarization filters for all angles
- High resolution via multi-angle particle sizing (MAPS)
Litesizer DLS 501
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- Three measurement angles for advanced dynamic light scattering
- Zeta potential determination with patented cmPALS
- Measurements of molecular mass and refractive index
- Fluorescent and polarization filters for all angles
- Particle sizing from 0.3 nm to 15 µm
Litesizer DLS 101
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- An affordable introduction to dynamic light scattering
- Wide sample coverage is ensured using DLS back-scatter detection
- Transmittance measurement to live-monitor sample behavior
- Particle sizing from 0.3 nm to 10 µm
Key Features
Three Angles, Real-Time Monitoring for Better Sizing
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With its automatic angle selection, Litesizer DLS eliminates errors while offering three detection angles for measuring a broad range of samples.
Advanced analytical precision is supported by the remarkable resolution provided by the Multi-Angle Particle Sizing (MAPS) measurement mode.
The continuous transmission monitoring, unique to the market, provides users with immediate information on sedimentation or agglomeration by providing real-time feedback on sample behavior during measurement.
The technology is the best option for precise, reliable particle analysis, as real-time information improves measurement quality and reliability.
Market-Leading Zeta Potential Analysis
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The patented cmPALS method of the dynamic light scattering instrument is specifically made to remove reproducibility concerns caused by aging effects.
Furthermore, the innovative design of the Omega Cuvette reduces the electrical field gradient, thereby improving reproducibility by ±3 %. With a zeta potential measuring particle size range of 1.3 nm to 100 µm, which leads the market, this device has the widest capability available, guaranteeing accurate and reliable results across a wide range of applications.
Kalliope: The Benchmark Software for Particle Sizing
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Very minimal user training is necessary for the Kalliope software.
It simply takes three clicks to complete measurements. Users can quickly review input settings, measurement signals, and findings, thanks to the distinctive one-page interface. With pre-established standard reports and well-organized result summaries, users can quickly obtain measurement results.
Use the advanced analysis features, Excel export options, and configurable report templates for additional in-depth study. Furthermore, Kalliope fully complies with 21 CFR Part 11, ensuring strong data integrity and regulatory compliance.
All the Measuring Modes Users Need
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The particle concentration measurement mode of the Litesizer DLS 701 enhances versatility by allowing concentration analysis of up to three different size populations in a single sample without calibration. Whether the users are utilizing single-angle DLS or MAPS, this mode can handle both monodisperse and polydisperse samples across a broad concentration range.
Additionally, to ensure the highest precision for particle size and zeta potential data, measure the refractive index of solvents at the precise wavelength and temperature of your experiments (European Patent 3 023 770). Refractive index readings from the Litesizer DLS 701 and DLS 501 are accurate to within ±0.5 %.
Finally, molecular mass measurement is another feature of the Litesizer DLS series.
Most Capable Filtering Options Available
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The only dynamic light scattering devices available that provide users the option to apply polarization or fluorescence filters in all three angle directions are the Litesizer DLS 701 and 501. Particle concentration analysis and MAPS three-angle or specific single-angle analysis with applied filters are enabled by this, making possible analyses that are not feasible with similar devices (e.g., quantum dot concentration determination).
Specifications
Source: Anton Paar GmbH
| |
Litesizer
DLS 701 |
Litesizer
DLS 501 |
Litesizer
DLS 101 |
| Particle size specifications |
| Measurement principle |
Dynamic Light Scattering (DLS) |
| Measuring range |
0.3 nm to 15 μm*
(particle diameter) |
0.3 nm to 10 μm*
(particle diameter) |
| Measurement angles |
15 °, 90 °, 175 °, Multi-angle particle sizing (MAPS) |
15 °, 90 °, 175 ° |
175 ° |
| Min. concentration |
0.1 mg/mL (lysozyme)
lower than 0.00001 % (0.1 ppm, Latex 100 nm) |
0.1 mg/mL (lysozyme) |
| Max. concentration |
50 % w/v (sample-dependent) |
| Min. sample volume |
1.5 µL |
12 µL |
| Accuracy |
Better than +/- 2 % on NIST traceable standards |
| Repeatability |
Better than +/- 2 % on NIST traceable standards |
| Particle Concentration Specifications |
| Analysis model |
Mie Theory |
- |
- |
| Measuring range |
108 - 1013 particles/mL (sample dependent) |
- |
- |
| Size limit |
1 µm |
- |
- |
| Measurement angles |
15 °, 90 °, 175 °, Multi-angle particle sizing (MAPS) |
- |
- |
| Min. sample volume |
12 µL |
- |
- |
| Accuracy |
+/- 10 % (sample dependent) |
- |
- |
| Repeatability |
+/- 5 % (sample dependent) |
- |
- |
| Zeta potential specifications |
| Measuring principle |
Electrophoretic Light Scattering (ELS) / cmPALS |
- |
| Measuring range |
>= +/- 1000 mV |
- |
| Mobility range |
10-11 m2/V.s to 2 x 10-7 m2/V.s |
- |
| Size range |
1.3 nm to 100 µm (diameter) |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Max. sample concentration |
70 % w/v (sample-dependent) |
- |
| Max. sample conductivity |
200 mS/cm |
- |
| Min. sample volume |
50 µL (sample-viscosity-dependent) |
- |
| Accuracy |
Better than +/- 10 % |
- |
| Repeatability |
+/- 3 % |
- |
| Molecular mass specifications |
| Measuring principle |
Static Light Scattering (SLS) |
- |
| Measuring range (mass) |
300 Da to 20 MDa |
- |
| Measuring range (particle size) |
Up to 40 nm (diameter) |
- |
| Measurement angle |
90 ° |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Accuracy |
+/- 10 % |
- |
| Repeatability |
+/- 5 % |
- |
| Transmittance specifications |
| Measuring range |
0 % to 100 % |
| Min. sample volume |
1.5 µL |
15 µL |
| Accuracy |
Better than +/- 1 % |
| Refractive index specifications |
| Measuring range |
1.28 to 1.50 |
- |
| Min. sample volume |
1 mL |
- |
| Accuracy |
+/- 0.5 % |
- |
| General specifications |
| Light source |
Semiconductor laser diode / 40 mW, 658 nm |
| Optical filters (fluorescence, vertical, and horizontal polarization) |
Forward, side, and backscattering |
- |
| Laser warm-up time |
6 min |
| Temperature control range |
0 °C to 120 °C |
| Ambient operating temperature |
10 °C to 35 °C |
| Humidity |
Up to 80 % non-condensing |
| Dimensions (W, D, H) |
450 mm, 505 mm, 135 mm |
| Weight |
Approx. 18 kg (40 lb) |
Approx. 16.3 kg (36 lb) |