The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

The Litesizer DIF series delivers precise particle sizing across a wide range from 10 nm to 3.5 mm, backed by nearly six decades of laser diffraction expertise. Featuring a best-in-class optical setup, it combines powerful 10 mW and 25 mW lasers with the industry’s broadest detected diffraction angle range, spanning 0.01° to 170°.

Designed for ease of use, the Kalliope software streamlines the measurement process - getting started takes just three clicks, with no extensive training required. The intuitive Quick-Click system enables fast, tool-free switching between dispersion units, reducing the risk of setup errors. Built-in safety features for both wet and dry dispersion ensure smooth, secure operation.

With a durable metal housing and an isolated optical bench, the Litesizer DIF performs reliably across a wide range of environments, from rugged industrial settings to advanced research labs.

Building on a legacy of innovation, the Litesizer DIF series represents the next step in laser diffraction technology - precision, made effortless.

Litesizer DIF 100

  • Measure samples from 0.1 µm to 1000 µm
  • Switch between liquid and dry dispersion in just one move
  • Kalliope software: No training needed, dedicated QC mode
  • Reliable results even in harsh environments

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Litesizer DIF 300

  • Measure samples from 0.1 µm to 2500 µm
  • Switch between liquid and dry dispersion in just one move
  • Kalliope software: No training needed, dedicated QC mode
  • Reliable results even in harsh environments
  • Compatible with the Liquid Flow Imaging dispersion unit

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Litesizer DIF 500

  • Measure samples from 0.01 µm to 3500 µm
  • Switch between liquid and dry dispersion in just one move
  • Kalliope software: No training needed, dedicated QC mode
  • Reliable results even in harsh environments
  • Compatible with the Liquid Flow Imaging dispersion unit

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Key Features

Particle Sizing in any Environment

The Litesizer DIF is designed to withstand the demands of heavy industrial environments, thanks to its high-quality components and sturdy metal housing.

Its robust construction ensures that no dust or powder can penetrate the optical bench, and the interior is isolated from direct vibrations at the production site. This exceptional durability translates into significant savings on upkeep and repair costs.

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Kalliope: The Benchmark Software for Particle Sizing

The Kalliope software is designed for immediate and intuitive use, featuring a one-page workflow that simplifies parameter setting, data acquisition, and results analysis. This streamlined process allows users to get results in just three clicks, significantly reducing training time.

For consistent, reliable results, the QC mode offers customizable user management and allows for the locking of delicate settings. In this mode, the instrument provides simple feedback on whether your product is within its defined limits.

A pharma option is available that includes robust data security functions, user management, and audit trails, making the software compliant with the US FDA’s 21 CFR Part 11 regulations.

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Efficient Dispersion, Maximum Safety

The Litesizer DIF’s Quick-Click feature connects dispersion units in a single, seamless step - there is no need for extra cables, tubes, or pipes. An integrated obscuration level indicator lets users monitor the sample amount in real time, ensuring accurate dosing from the very beginning.

For dry samples, the Dry Jet dispersion unit includes a suction check and a built-in dust cover to help prevent powder from spreading.

The Liquid Flow unit automatically verifies that there is enough liquid before starting sonication, reducing the risk of overheating. A high-resistance module is available to handle chemically demanding samples in particularly aggressive media.

Additionally, the Liquid Flow Imaging unit combines laser diffraction with dynamic image analysis, enabling users to capture particle shape parameters starting from 5 µm in size.

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

On Quality, Anton Paar Leads the Way

The Litesizer DIF is the ideal tool for particle analysis due to its high-quality manufacturing and high-grade hardware, which allows it to collect superior raw data.

This single laser diffraction particle size analyzer can measure a broad range of samples, covering particle sizes from 0.01 µm to 3500 µm, without the need for additional investments.

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Less Investment, Saved Bench Space – Compatibility Across the Board

The dispersion units used with Anton Paar’s Litesizer DIA and Litesizer DIF instruments are fully compatible, helping reduce overall investment costs and optimize lab space.

Plus, all Litesizer instruments can be operated from a single PC running the Kalliope software, simplifying workflows and minimizing equipment footprint.

The Ultimate Guide to Choosing a Laser Diffraction Particle Size Analyzer

Image Credit: Anton Paar GmbH

Specifications

Source: Anton Paar GmbH

  Litesizer DIF 500 Litesizer DIF 300 Litesizer DIF 100
Measurement principle Laser Diffraction (Mie and Fraunhofer scattering)
Measurement range 0.01 μm - 3,500 μm 0.1 μm - 2,500 μm 0.1 μm - 1,000 μm
Size classes 144 (user adjustable) 114 (user adjustable) 104 (user adjustable)
Accuracy * better than ± 0.5 % variation***
Repeatability better than ± 0.5 % variation***
Reproducibility** better than ± 1 % variation***
Possible measurement duration <10 sec
Data acquisition rate 16 kHz
Light source 1  
Type Fiber coupled laser diode
Optical arrangement Reverse Fourier
Wavelength 830 nm, infrared
Power 10 mW
Laser Class Class 1 (IEC60825-1)
Light source 2 Litesizer DIF 500 -
Type Diode laser -
Optical arrangement Tilted relative to IR laser -
Wavelength 450 nm, blue -
Power 25 mW -
Laser Class Class 1 (IEC60825-1) -
Detectors  
Type Log-spaced photo diode array and single diodes for side and back-scattering
Angular range 0.01° - 170° 0.01° - 155°  
Focal length 300 mm
Alignment Automatic
Instrument data  
Instrument dimensions**** 400 mm x 790 mm x 290 mm (H x W x D)
Instrument weight**** 42.3 kg (93.2 lb)
Power supply 100 V to 240 V ±10 %, 50/60 Hz

Trademarks: 
• Kalliope (EU: 012709391), (UK: UK00912709391) 
• Litesizer (EU: 011695491), (UK: UK00911695491) 

* Defined for a monomodal latex standard and accounting for the manufacturer's uncertainty of standard size. 
** Defined for D50 of a polydisperse standard. 
*** Sample and preparation dependent. Defined for liquid dispersion measurements. 
**** Without PC and dispersion unit

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