EVA Karl Fischer Titrators for Reliability

Experience EVA Karl Fischer Titrators, a comprehensive product line that includes volumetric and coulometric solutions. Advanced engineering meets intelligent software to improve precision and efficiency.

These titrators use the Fast Forecasting Amperometric (FFA^™) Algorithm and dSens M143 sensor to quickly and accurately determine water content. The Swiss-made modular design meets a wide range of laboratory requirements, increasing throughput and ensuring consistent results.

• High efficiency: The FFA^™ control algorithm enables rapid water-content titrations that increase throughput without losing accuracy
• Versatility: Any lab footprint can be accommodated via modular design, which ranges from standalone benchtop installations to completely automated racks
• Seamless workflows: Method setup, data capture, and CFR-ready reporting are all combined with the OneClick^™ touchscreen and LabX^™ software
• Optimal safety: Users and benches are protected by closed-loop solvent exchange and spill-proof cell design
• Regulatory Compliance: EU Annex 11 and 21 CFR Part 11 regulations are supported via integrated audit trails and e-signatures
• Sustainable practices: Low-solvent methods, ethanol-based reagents, and paperless documentation save chemical consumption and waste

Video Credit: Mettler-Toledo - Titration

Highlight

Understand How the FFA^™ Algorithm Works

The video explains the Fast Forecasting Amperometric (FFA^™) Algorithm in EVA Karl Fischer Titrators. Discover how this sophisticated feature automatically changes reagent concentrations for faster, more accurate titrations, boosting laboratory efficiency and precision in water content measurement.

Video Credit: Mettler-Toledo - Titration

Features

Rapid Results, Reliable Science. Discover EVA's Edge

High Efficiency

• Fast Forecasting Amperometric (FFA^™) Algorithm: Uses cutting-edge control technology to optimize reagent concentration and accelerate reaction rates for an accurate and timely assessment of water content.
• Rapid-Response Digital Sensor: With the interference-free dSens M143 sensor installed, it can record data quickly and accurately for dependable outcomes.
• Precision Titrant Addition: A high-resolution dDrive unit with 120,000 steps is used in V1 and V3, offering accurate dispensing that adapts automatically to sample demands.

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Swiss Versatility

• Swiss craftsmanship: These titrators are well-known for their dependability and quality, and they are made to satisfy the stringent standards of modern laboratories.
• Plug-and-Measure: Modules snap in instantaneously, allowing users to adjust burettes, sensors, and cells as workflows change
• Versatile applications: Extensive accessory choices provide interoperability with different sample types, meeting varying industry needs.

Seamless Workflow

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• Intuitive OneClick^™ interface: Simplifies lab procedures and improves usability for all skill levels.
• Automated workflow: Reduces transcription mistakes by transferring sample weight data and titrant information instantly. Convenient features such as automated sample identification and process initiation improve overall efficiency significantly.
• Seamless LabX^™ integration: Connects to LIMS, ELN, MES, and CDS to lower IT costs and increase efficiency.
• InMotion Autosampler: Allows unattended processes from low to high throughput, with optional oven extraction for difficult samples and little operator involvement. Compatible with V1/V3 and C1/C3 titrators.

Regulatory Compliance and Traceability

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EVA Karl Fischer Titrators seamlessly interact with LabX^™, improving data administration and ensuring regulatory compliance with standards such as 21 CFR Part 11 and EU Annex 11. Centralized user control, electronic signatures, and thorough audit trails are among the key features. Adherence to the ALCOA++ principles improves data integrity while facilitating validation and maintenance.

Optimal Safety

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• Advanced solvent management: Automates chemical distribution to prevent exposure and leakage, resulting in a safer and cleaner laboratory environment.
• Remote operation capabilities: The device has a detachable touchscreen, a 2.5-m connection, and a OneClick^™ interface for safe remote control, decreasing the danger of exposure to dangerous substances.
• Safety-driven design: Uses an enclosed system to avoid spills and limit chemical handling, hence safeguarding people and ensuring consistent titration accuracy.

Sustainable Practices

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EVA Karl Fischer Titrators and LabX^™ software promote paperless processes and decrease resource usage, leading to more sustainable laboratory operations. They promote environmentally friendly lab practices by simplifying operations, improving repeatability, and reducing mistakes.

Their design minimizes solvent use, particularly in ultra-low water content determinations, lowering both costs and environmental impact while providing rapid, accurate titrations for modern, environmentally conscious laboratories.

Methods

Volumetric or Coulometric? Match the Method to the Needs

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Selecting between volumetric and coulometric titration guarantees the best match for the lab. Volumetric is ideally suited for high water content in food, pharma, and chemicals, whereas coulometric excels at ultra-low detection in petrochemicals, plastics, and electronics. EVA Karl Fischer Titrators respond to sample and process requirements.

Instruments

Volumetric Karl Fischer Titrators

These volumetric devices provide quick, consistent readings throughout water content ranges of 100 ppm to 100 %. Their modular design is suitable for a wide range of sample types and high-throughput labs, combining Swiss accuracy with modern control algorithms to improve efficiency and reliability.

EVA Karl Fischer Titrator V1

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Precision simplified: The EVA V1 Titrator excels in determining water content in soluble materials quickly and accurately. Its simplicity and effectiveness make it ideal for routine testing.

Simplify the Lab’s Routine with Precision

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• Top performance: Measurement of simple liquids and solubles ensures quick and accurate water content measurement.
• Ease of use: Designed with the user in mind, routine tests are simplified, and complicated settings become more approachable.
• Optimal choice: Ideal for laboratories looking to increase productivity and operational excellence.
• Streamlined operations: Improve the lab’s throughput by using an instrument designed for high-volume testing with little complexity.

EVA Karl Fischer Titrator V3

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The EVA V3 Titrator offers greater adaptability in determining water content in various sample types. It includes a homogenizer attachment, external sample extraction, and integration with the InMotion KF autosampler for high-throughput automation - perfect for even the most difficult applications.

Master Complex Samples with Precise Efficiency

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• Wide Sample Compatibility: The V3 handles semi-solids and complex matrices with speed and precision, and it includes a homogenizer attachment for reliable, uniform results.
• External Extraction: Isolate water from non-dissolving samples to safeguard the main unit while successfully controlling reactive or corrosive materials.
• High-Throughput Automation: Integrate the InMotion KF autosampler to effectively handle many samples, increasing overall lab productivity.

Coulometric Karl Fischer Titrators

For ultra-low water content (1 ppm – 5 %), these coulometric systems combine optimized reagent use with sophisticated algorithms to provide fast studies without losing trace-level sensitivity for batteries, electronics, petrochemicals, and specialty chemicals.

EVA Karl Fischer Titrator C1

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The EVA C1 Titrator simplifies trace-level precision while delivering rapid and precise results. Optimized reagent utilization and powerful algorithms ensure that speed does not sacrifice trace-level sensitivity, making it vital in industries such as batteries, electronics, petrochemicals, and specialty chemicals.

Achieve Ultra-Low Detection with Confidence

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• Uncompromising Accuracy: FFA^™ technology enables rapid and reproducible measurements for trace-level applications.
• Ease of Use: Simple operation shortens training time, making daily work more efficient.
• KF Hybrid Cell: The sealed, easy-to-clean construction guarantees safe solvent interchange and automatic/manual switching.
• Efficiency and Sustainability: Minimal reagent consumption reduces expenses and promotes environmentally responsible lab practices.

EVA Karl Fischer Titrator C3

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Automated trace-level versatility: Building on the C1's characteristics, the EVA C3 Titrator interacts effortlessly with the InMotion KF autosampler to enable high-throughput operations. It is designed to handle complicated matrices and greater sample quantities, producing precise, efficient results in demanding lab situations.

Elevate the Trace-Level Analyses

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• High-Throughput Analysis: Automate multiple sample measurements to reduce manual involvement while increasing efficiency.
• Advanced Sample Handling: External extraction and blank management can accommodate specialized solvents and difficult matrices.
• Workflow Optimization: Intelligent algorithms guarantee that reagents are used efficiently while producing rapid and precise results, even in complicated or high-volume operations.

Accessories

Boost Lab Capabilities with Advanced Accessories

Experience Wide-Ranging Analytical Flexibility for Diverse Applications

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Enhance the analysis with specialist accessories, such as thermostable vessels, homogenizer adapters, and drying ovens. These tools make it easier to work with difficult samples and obtain accurate findings. Customize the Karl Fischer process with choices such as different burette sizes and longer terminal cables for additional convenience and versatility.

Services

Global Reach Meets Reliable Care

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• Installation and qualification: IPac and EQPac provide expert setup, inspections, and compliance training for regulated industries.
• Calibration and documentation: Regular calibration and traceability software provide long-term accuracy and compliance.
• Extended care and support: Provides 24-month coverage and biannual maintenance, supported by a global support network to ensure minimal downtime.

Applications

Volumetric Applications

Determining Water Content in Antibiotics Using a Thermovessel with EVA Karl Fischer Titrators

To reliably test the water content of antibiotics, use a thermovessel with an EVA Karl Fischer Titrator. The regulated temperature increase allows for the efficient release of water from solid drugs, resulting in precise and reliable analysis, which is crucial for quality assurance.

Analyzing Water Content in Gummy Bears Using EVA Karl Fischer Titrators

Use the EVA V3 Titrator with a homogenizer for quick and simple sample dispersion to precisely measure the water content of gummy bears. The water content of high-moisture food samples, such as gummy bears, may be effectively determined with this setup, guaranteeing accurate and trustworthy analysis essential for maximizing texture and shelf life.

Analyzing Water Content in Acetone Using EVA Karl Fischer Titrators

The methanol in the KF reagents interacts with acetone, an organic solvent utilized extensively in several market areas. Higher water contents are the result of more water being generated. Using the EVA Karl Fischer Titrators, the water content of acetone may be determined quickly and reliably by suppressing the side reaction using specific methanol-free reagents.

Performing General System Suitability Test (GSST) with Direct Injection Using EVA Karl Fischer Titrators

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For effective analysis, prepare the sample in accordance with the GSST procedure and make use of the EVA Karl Fischer Titrators' direct injection capability. This technique maintains adherence to strict analytical standards while improving the accuracy and speed of water content measurement across a range of samples.

Determining Concentration with Sodium Tartrate Using EVA Karl Fischer Titrators

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Before starting the sample titration, it is essential to exactly ascertain the KF titrant’s present concentration to get correct findings. For this reason, sodium tartrate is a great reference material. Make sure to weigh it precisely and dissolve it in the KF solvent. By taking this important step, users can use the EVA Karl Fischer Titrator to determine the titrant concentration, guaranteeing the accuracy of all further sample tests.

Determining Water Content in Tea Leaves Using External Extraction with EVA Karl Fischer Titrators

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Longer analysis times result from the delayed release of water from insoluble particles into the KF solvent. External extraction moves the laborious water extraction process to an external vessel.

This guarantees that while the solvent removes the water, the EVA Karl Fischer Titrator will not become clogged for minutes or hours. To fulfill the unique requirements of solid samples, such as tea leaves, the water content is removed and passed to the titrator for an accurate and comprehensive evaluation.

Analyzing Water Content in Honey with EVA Karl Fischer Titrators Using Formamide

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Understanding water content in food is critical for evaluating product shelf life during storage and transportation, as well as edible quality. Accurately evaluating water content is therefore critical in manufacturing operations and quality control.

Honey is difficult to dissolve in the KF solvent; thus, formamide is employed as an auxiliary solvent to achieve full dissolution. Proper sample preparation ensures precise quantification and better accuracy when analyzing water with the EVA Karl Fischer Titrator.

Measuring Water Content in Edible Oils with EVA Karl Fischer Titrators

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Use a solution of decanol and chloroform to make the edible oil samples more soluble in the Karl Fischer solvent. For accurate and trustworthy water content measurement - which is crucial for determining the quality and shelf life of edible oils - directly add them to the EVA Karl Fischer Titrator.

Advancing Lab Safety and Sustainability with Ethanol-Based Reagents in EVA Karl Fischer Titrators

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EVA Karl Fischer Titrators offer a more environmentally friendly substitute for traditional methanol by supporting ethanol-based reagents. Ethanol’s poorer reactivity has historically resulted in longer titration times and less precision.

These problems have been solved because of developments in measurement algorithms and contemporary reagent compositions. With these safer and more environmentally friendly ethanol-based reagents, labs can carry out precise titrations without compromising speed or accuracy, improving sustainability.

Ensuring Accuracy in Karl Fischer Titration: Suitability Test According to Ph. Eur. 2.5.12.

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Chapter 2.5.12 of the European Pharmacopeia describes a suitability test for the volumetric Karl Fischer titration method. Check the precision of the water content calculation for a specific sample, titrant, and solvent combination.

Coulometric Applications

Isolating Trace Water in Mineral and Crude Oils with EVA Karl Fischer Titrators

Heavy petroleum products can retain water at ultra-low levels, challenging direct titration. When paired with external extraction techniques, the EVA C3 enables effective isolation and quantification of trace water. Its automation capabilities further simplify multi-sample workflows - ideal for high-throughput applications in the petrochemical industry.

Determining Water Content in Plastics and Polymers Using an Oven with EVA Karl Fischer Titrators

Plastic pellets and polymers are often challenging to dissolve in KF solvents, necessitating specialized techniques for water release. When paired with the InMotion KF Oven autosampler, the EVA C3 Titrator efficiently heats samples to extract moisture. This configuration reduces operator involvement while ensuring the high accuracy required for R&D and quality control in polymer applications.

Comprehensive Battery and Electronics Testing with EVA Karl Fischer Titrators

The EVA C3 Titrator and the InMotion KF Oven offer an integrated testing platform for battery materials, including active materials, cathodes, anodes, and electrolytes. Solid components can be heated to release moisture, or electrolytes can be directly injected - all within a single automated system. This setup ensures consistent ppm-level accuracy, essential for battery and electronics manufacturing.