Achieve Exit Gas Analysis of Bioprocesses with the QIC BioStream


The QIC biosteam is designed for the continuous analysis of gases and vapours from multiple fermentation reactors and has multi off gas and multi reactor dissolved gas species analysis capability.

The system features Hiden’s advanced 'Proteus' Multi-stream selector valve along with an accurate, ultra-stable triple filter mass analyzer. Low internal dead volume and quick data acquisition enable switching times of less than 10 seconds for each stream.


  • The system features 20-, 40- and 80-way sample configurations and an integral thermocouple or heater of up to 120 °C
  • Gas flows from 0.01 to 10 L per minute at pressures ranging from 10 mbar to 2 bar, with 100 amu profile in 2.5 seconds
  • Strong, flexible and heated QIC direct inlet has less than 500 ms response to vapors or gases
  • High sensitivity (to 5 ppb) and stability (< ±0.5% height variation, 24 hours), up to 510 amu
  • Zero 'crosstalk' for low memory effects and low dead volume for a quick response
  • Direct-drive, high-torque microstepping motor comes with an incremental rotary encoder for closed-loop motion and home z-position
  • The latest face-sealing technology offers an effective and durable seal (>6 × 106 events)
  • Windows ™—MASsoft control through Ethernet LAN, RS485, or RS232
  • Soft ionization for analyzing complex organics
  • Motion management, such as bi-directional travel for shortest path, error annunciation, position maintenance, and intelligent acceleration or deceleration

Key Features

  • Hiden 3F ultra-stable mass spectrometer
  • Rapid port switching
  • Quantitative gas analysis of up to 32 species
  • High flow configuration of up to 10 L/minute
  • Proteus 20, 40, or 80-way multi-port switching options are available
  • Low flow configuration from 4 mL/minute
  • OPC Server technology for process control
  • Dissolved species analysis
  • Respiratory Quotient (RQ)
  • CO2 Evolution Rate (CER)
  • Oxygen Uptake Rate (OUR)


  • Biogas production monitoring
  • Fermentation process analysis
  • Synthetic process analysis
  • Mammalian cell culture analysis
  • Reaction profile studies
  • Spatially resolved MS
  • High-purity gas analysis
  • Fuel cells
  • Fermentation
  • Environmental monitoring
  • Gas production and storage

Technical Specifications of QIC BioStream

Source: Hiden Analytical

Mass Range
  • 200 or 300 amu
Operating Modes
  • Process trend analysis
  • Bar Scan
  • Profile Scan
Mass Spectrometer
  • Precision Triple Filter Quadrupole - 200 amu is standard
  • 20, 40 or 80-way multiplexed inlet multiple stream sampling
Data Acquisition & Control
  • Windows 7/8/10 compatible with Ethernet, USB and serial connections
  • QIC BioStream System             1050 mm x 550 mm x 1260 mm
  • QIC BioStream-C bench-top     530 mm x 535 mm x 936 mm


Fermenter Sampling

Shown below is a standard system setup for sampling from numerous fermenters, configured with sample lines, sample conditioning components, and flow control valves to house reactors with flows ranging from 100 mL/minute up to >10 L/minute.

Achieve Exit Gas Analysis of Bioprocesse with the GIC BioStream

Image Credit: Hiden Analytical

Other Equipment by this Supplier

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.