Zetasizer Lab—Entry-Level Particle Size and Zeta Potential Analyzer with Enhanced Capabilities

The entry-level Zetasizer available from Malvern Panalytical does not compromise on features. The Zetasizer Lab integrates Adaptive Correlation, M3-PALS, and constant current zeta mode.

Moreover, the Zetasizer Lab comes with ZS Xplorer, a user-friendly analytical software. ZS Xplorer provides instant feedback on data quality and guides users on how to enhance their results.


Image Credit: Malvern Panalytical

Features and Benefits

The Zetasizer Lab is the ideal entry-level system that offers an extensive range of features, such as:

  • DLS analysis: particle size measurements ranging from 0.3 nm to 10 μm
  • Zeta potential of nanoparticles and colloids is provided by making use of M3-PALS analysis and constant current zeta mode
  • Molecular weight measured using Static Light Scattering at 90°
  • Enables use of low volume disposable capillary cell for size measurements in sample volumes as low as 3 μL
  • Wider size range analysis provides enhanced precision for particle sizes above 1 μm and indicative results above 10 μm (with the help of ZSU1002 Low Volume Disposable Sizing Cell)
  • Comes in Red Label and Blue Label models:
    • Users can choose Red Label for more difficult sample types, like low solid content samples, surfactant solutions and proteins
    • Users can select Blue Label for regular sample investigation like pigments, metal oxides and metallic colloids
  • On-site upgradeability available to either Zetasizer Ultra or Zetasizer Pro models

Key Applications

The Zetasizer Lab can be utilized for several applications, such as the following:


In several academic labs throughout the world, the Zetasizer Lab is a significant analytical tool, which finds use in all applications where particle or molecular size and zeta potential analysis are needed.

Thanks to the range of applications covered by Zetasizer systems, together with several thousands of scientific citations, these instruments have gained a central space in several scientific faculties.


The stability of biological molecules is affected by changes in external temperature, level of agitation, molecule concentration, and time. Mainly, instabilities lead to aggregation and denaturation of the molecule, which makes them lose their biological function, elicit an immune response, and thus restrict its therapeutic viability.

Hence, factors influencing therapeutic efficacy and immunogenicity must be tracked over the entire development pipeline particularly at initial stages to de-risk the biological drug molecule and prevent late-stage failures.

The Zetasizer range offers high-quality, stability-indicating data for biological drug molecules in a short period, thereby allowing the measurement to be applied over the entire development pipeline.

Food and Drink

Zetasizer systems are employed to analyze particle size and zeta potential to enhance the taste and appearance of drinks, foods, and flavorings, as well as improve the dispersion and emulsion stability to increase the shelf life of products and enhance the performance of products.


Zetasizer measurements of nanoparticle size distribution, stability, dispersion properties and tendency to aggregate are vital for designing new nanomaterials. The very huge surface area of these materials might lead to improved chemical and physical properties, like enhanced solubility, better catalytic activity, or unanticipated toxicological or optical behavior.

Paints, Inks, and Coatings

Formulations of paints, inks, and coatings should be stable to maintain them in an ideal state over time without aggregation or change. Particle size and zeta potential quantified by the Zetasizer instruments thus have crucial roles in identifying the properties of products, like color, finish, strength, durability, dispersibility and shelf life.


Accurate measurement of particle size and zeta potential can guarantee the production of effective therapeutics, delivered safely. Zetasizer systems help characterize the quality and stability of emulsions, dispersions, and creams, thus minimizing formulation time and accelerating the launch of new products to market.

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